Evidence map›Paper›PMID 30078709›Full record

ArticleCell2018

Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity.

Brikha R Shrestha, Chester Chia, Lorna Wu, Sharon G Kujawa, M Charles Liberman, Lisa V Goodrich

Open access · bronzeAbstract read
In one paragraph

Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 279 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
279citing papers in PubMed, 2 pooled it
24.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

279 citing papers in PubMed, 2 syntheses or guidelines pooled it, 448 citations in OpenAlex.

  1. Utilizing Single Cell RNA-Sequencing to Implicate Cell Types and Therapeutic Targets for SSNHL in the Adult Cochlea.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2021
    Pooled it
  2. Pooled it
  3. Article
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  9. Functionalized Biomimetic Scaffolds for Human-Derived Auditory Neural Circuit Construction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Article
  11. Spontaneous Calcium Signalling in the Developing Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Neural Hearing Loss: Mechanisms, Diagnosis and Treatment Horizons.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Cochlear Implant Insertion Trauma Is Associated With Spiral Ganglion Neuron "Dead Zones" in the Human.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026
    Article

219 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brikha R ShresthaDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Chester ChiaDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Lorna WuDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Sharon G KujawaDepartment of Otolaryngology, Harvard Medical School, Boston, MA 02115, USA; Eaton-Peabody Laboratories, Massachusetts Eye & Ear Infirmary, Boston, MA 02114, USA.
M Charles LibermanDepartment of Otolaryngology, Harvard Medical School, Boston, MA 02115, USA; Eaton-Peabody Laboratories, Massachusetts Eye & Ear Infirmary, Boston, MA 02114, USA.
Lisa V GoodrichDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: lisa_goodrich@hms.harvard.edu.
Harvard University · US

Funding

Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MARGARET S LIVINGSTONE · 1998 to 2026
$21.3M
Training in the Molecular Biology of Neurodegeneration and Alzheimer's DiseaseT32AG000222 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Bruce A YANKNER · 1992 to 2026
$18.5M
SINGLE-NEURON MARKING IN THE STUDY OF ABNORMAL COCHLEASR01DC000188 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Gabriel Corfas, M. Charles Liberman · 1989 to 2026
$15.1M
Genetic Dissection of Auditory Circuit AssemblyR01DC009223 · NIDCD · HARVARD MEDICAL SCHOOL · PI Lisa Goodrich · 2009 to 2026
$8.4M
FUNDAMENTAL NEUROBIOLOGYT32NS007484 · NINDS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI REGEHR, WADE G · 2000 to 2014
$5.9M
Orchestra: A high performance biomedical supercomputing collaborativeS10RR028832 · NCRR · HARVARD MEDICAL SCHOOL · PI DANUSER, GAUDENZ · 2010 to 2010
$3.7M
Afferent-efferent interactions in the developing cochleaR01DC015974 · NIDCD · HARVARD MEDICAL SCHOOL · PI GOODRICH, LISA · 2017 to 2021
$2.4M
Molecular and anatomical correlates of spiral ganglion neuron heterogeneityF32DC014371 · NIDCD · HARVARD MEDICAL SCHOOL · PI SHRESTHA, BRIKHA RAJ · 2015 to 2016
$112k
Genetic Dissection of Auditory Circuit AssemblyR56DC009223 · NIDCD · HARVARD MEDICAL SCHOOL · PI GOODRICH, LISA · 2014 to 2014
$100k
NCRR NIH HHS S10 RR028832NEI NIH HHS P30 EY012196NIA NIH HHS T32 AG000222NIDCD NIH HHS F32 DC014371NIDCD NIH HHS R01 DC000188NIDCD NIH HHS R01 DC009223NIDCD NIH HHS R01 DC015974NIDCD NIH HHS R56 DC009223NINDS NIH HHS T32 NS007484
6 · The paper itself

Abstract

In the auditory system, type I spiral ganglion neurons (SGNs) convey complex acoustic information from inner hair cells (IHCs) to the brainstem. Although SGNs exhibit variation in physiological and anatomical properties, it is unclear which features are endogenous and which reflect input from synaptic partners. Using single-cell RNA sequencing, we derived a molecular classification of mouse type I SGNs comprising three subtypes that express unique combinations of Ca

Indexed as

Amino Acid Transport Systems, AcidicAnimalsCalbindin 2CochleaDeafnessEar, InnerFemaleHair Cells, Auditory, InnerMaleMiceMice, Inbred C57BLSensory Receptor CellsSequence Analysis, RNASpiral GanglionSynaptic TransmissionTransgenesAmino Acid Transport Systems, AcidicCalb2 protein, mouseCalbindin 2Slc17a8 protein, mouseactivity-dependent developmentauditoryneuronal subtypesneuron heterogeneitysingle-cell RNA-seqspiral ganglion neuronsspontaneous activityVglut3

Identifiers

PMID30078709
PMCPMC6150604
OpenAlexW2886288118

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.