Evidence map›Paper›PMID 30078701›Full record

ReviewTrends in parasitology2018

Apicomplexa Cell Cycles: Something Old, Borrowed, Lost, and New.

Michael W White, Elena S Suvorova

Erratum issuedAbstract readReview
In one paragraph

Review in Trends in parasitology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. Article
  3. The Centrocone Protein SMC_N1 Is Important for the Proliferation ofAnimals : an open access journal from MDPI · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Orthologs ofMicrobiology spectrum · 2024
    Article
  17. Article
  18. Article
  19. The Crk4-Cyc4 complex regulates GThe EMBO journal · 2024
    Article
  20. The molecular mechanisms driving Plasmodium cell division.Biochemical Society transactions · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Michael W WhiteDepartment of Global Health, College of Public Health, University of South Florida, Tampa, FL 33612, USA.
Elena S SuvorovaDepartment of Global Health, College of Public Health, University of South Florida, Tampa, FL 33612, USA. Electronic address: essuvorova@gmail.com.

Funding

Developmental switches regulating tissue cyst formationR01AI124682 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI WHITE, MICHAEL W · 2017 to 2021
$2.8M
Studies of DNA Licensing in Apicomplexa ParasitesR01AI122760 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI WHITE, MICHAEL W · 2016 to 2020
$2.6M
Centrosome control of Toxoplasma growthR01AI109843 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI WHITE, MICHAEL W · 2014 to 2018
$2.4M
NIAID NIH HHS R01 AI109843NIAID NIH HHS R01 AI122760NIAID NIH HHS R01 AI124682
6 · The paper itself

Abstract

Increased parasite burden is linked to the severity of clinical disease caused by Apicomplexa parasites such as Toxoplasma gondii, Plasmodium spp, and Cryptosporidium. Pathogenesis of apicomplexan infections is greatly affected by the growth rate of the parasite asexual stages. This review discusses recent advances in deciphering the mitotic structures and cell cycle regulatory factors required by Apicomplexa parasites to replicate. As the molecular details become clearer, it is evident that the highly unconventional cell cycles of these parasites is a blending of many ancient and borrowed elements, which were then adapted to enable apicomplexan proliferation in a wide variety of different animal hosts.

Indexed as

Cell CycleApicomplexaHost-Parasite InteractionsProtozoan InfectionsApicomplexacell cyclecyclin-dependent kinaseevolutionmitosisToxoplasma gondii

Identifiers

PMID30078701
PMCPMC6157590

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.