ArticleCurrent biology : CB2018
A Novel Eukaryotic Denitrification Pathway in Foraminifera.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 125 citations in OpenAlex.
- The diversity of terminal electron acceptors across eukaryotes.Trends in biochemical sciences · 2026Review
- Mitochondrial Genome Reduction and Accelerated Evolution in Planktonic Foraminiferans.MicrobiologyOpen · 2026Article
- Unravelling Evolutionary and Ecological Insights of Foraminifera by Using Next Generation Sequencing: A Review.Biochemical genetics · 2026Review
- The Rise of Algae promoted eukaryote predation in the Neoproterozoic benthos.Science advances · 2025Article
- Article
- Array of metabolic pathways in a kleptoplastidic foraminiferan protist supports chemoautotrophy in dark, euxinic seafloor sediments.The ISME journal · 2025Article
- Endogenous glycoside hydrolases reveal foraminiferal capacity to degrade terrestrial and marine polysaccharides.ISME communications · 2025Article
- A unique symbiosome in an anaerobic single-celled eukaryote.Nature communications · 2024Article
- Horizontal gene transfer in eukaryotes: aligning theory with data.Nature reviews. Genetics · 2024Review
- Novel Alphaproteobacteria transcribe genes for nitric oxide transformation at high levels in a marine oxygen-deficient zone.Applied and environmental microbiology · 2024Article
- Phylogenetics and environmental distribution of nitric oxide-forming nitrite reductases reveal their distinct functional and ecological roles.ISME communications · 2024Article
- A deep-learning automated image recognition method for measuring pore patterns in closely related bolivinids and calibration for quantitative nitrate paleo-reconstructions.Scientific reports · 2023Article
- Article
- Trophic strategies of intertidal foraminifera explored with single-cell microbiome metabarcoding and morphological methods: What is on the menu?Ecology and evolution · 2022Article
- Methane Production by Facultative Anaerobic Wood-Rot Fungi via a New Halomethane-Dependent Pathway.Microbiology spectrum · 2022Article
- Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Denitrification in foraminifera has an ancient origin and is complemented by associated bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- First report of mitochondrial COI in foraminifera and implications for DNA barcoding.Scientific reports · 2021Article
- A microbial eukaryote with a unique combination of purple bacteria and green algae as endosymbionts.Science advances · 2021Article
- Multiple integrated metabolic strategies allow foraminiferan protists to thrive in anoxic marine sediments.Science advances · 2021Article
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10 authors at 2 institutions in 1 country.
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Abstract
Benthic foraminifera are unicellular eukaryotes inhabiting sediments of aquatic environments. Several species were shown to store and use nitrate for complete denitrification, a unique energy metabolism among eukaryotes. The population of benthic foraminifera reaches high densities in oxygen-depleted marine habitats, where they play a key role in the marine nitrogen cycle. However, the mechanisms of denitrification in foraminifera are still unknown, and the possibility of a contribution of associated bacteria is debated. Here, we present evidence for a novel eukaryotic denitrification pathway that is encoded in foraminiferal genomes. Large-scale genome and transcriptomes analyses reveal the presence of a denitrification pathway in foraminifera species of the genus Globobulimina. This includes the enzymes nitrite reductase (NirK) and nitric oxide reductase (Nor) as well as a wide range of nitrate transporters (Nrt). A phylogenetic reconstruction of the enzymes' evolutionary history uncovers evidence for an ancient acquisition of the foraminiferal denitrification pathway from prokaryotes. We propose a model for denitrification in foraminifera, where a common electron transport chain is used for anaerobic and aerobic respiration. The evolution of hybrid respiration in foraminifera likely contributed to their ecological success, which is well documented in palaeontological records since the Cambrian period.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.