Evidence map›Paper›PMID 30078460›Full record

ReviewLancet (London, England)2018

Autism spectrum disorder.

Catherine Lord, Mayada Elsabbagh, Gillian Baird, Jeremy Veenstra-Vanderweele

8 registry-linked trialsAbstract readReview
In one paragraph

Review in Lancet (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 1,109 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,109citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06292520 nacompletednot on this mapstarted 2023, after this paper: background citation

ABLLS-R and Portage Guide in the Development of Receptive Language Skills in Children With Autism Spectrum Disorder.

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled12ConditionsAutism Spectrum Disorders, Non-verbal Learning DisorderArmsPortage Guide Protocol, ABLLS-R protocol
NCT06415539 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effect of Vestibular and Proprioceptive Exercise Practices on Hyperactivity Levels in Children With Autism Spectrum Disorder

TypeinterventionalSponsorUskudar UniversityRan2022 to 2023Enrolled22ConditionsAutism Spectrum Disorder, AutismArmsclassical physical therapy program, exercises
NCT06468072 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Exploring the Impact of Theatrical Expressive Tasks in Children With Autism Spectrum Disorder (ASD).

TypeinterventionalSponsorIstituto per la Ricerca e l'Innovazione BiomedicaRan2024 to 2026Enrolled20ConditionsAutism, Autism Spectrum DisorderArmsExpressivity protocol for children with autism, Expressivity protocol for non-autistic children
NCT06662591 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

A Multi-Center Multi-Omics Approach for Investigating Genetic and Epigenetic Mechanisms in Autism Spectrum Disorder

Typeobservational_patient_registrySponsorResearch and Treatment Society of Genetic DisordersRan2025 to 2028Enrolled3,000ConditionsAutism Spectrum Disorder (ASD)
NCT07104708 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Systematic Exercise Training on Core Symptoms, Executive Function and Brain Function in Children With ASD

TypeinterventionalSponsorChen LiRan2025 to 2028Enrolled70ConditionsAutism Spectrum DisorderArmsThe Child-Parent- Trainer exercise program, The regular physical training
NCT07163949 completednot on this mapstarted 2024, after this paper: background citation

Balance In Children With Autism Spectrum Disorder: The Role Of Foot Posture And Anthropometry

Typeobservational_patient_registrySponsorGulhane School of MedicineRan2024 to 2025Enrolled22ConditionsAutism Disorder, Balance, Posture, Foot AnomaliesArmsPerformance-based tests (such as TUG, foot posture measurements, Tandem Gait test) will be administered to children with ASD.
NCT07578987 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Kinetic Sand on Functional Reach and Eye-Hand Coordination in Children With Autism

TypeinterventionalSponsorRiphah International UniversityRan2025 to 2026Enrolled17ConditionsAutism Spectrum DisorderArmsKinetic Sand Play
NCT07594171 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparative Outcomes of VR and In-person NDBI-informed Social Skills Interventions for Preschool-aged Children With Autism Spectrum Disorder

TypeinterventionalSponsorNational Cheng-Kung University HospitalRan2023 to 2025Enrolled32ConditionsAutism Spectrum Disorder High-Functioning, Autism Spectrum Disorder (ASD)ArmsVirtual Reality-Based Social Skills Group Intervention, In-Person Social Skills Group Intervention
3 · Its place in the literature

Who cites it

1,109 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  12. Gut microbes · 2026
    Article
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  15. Drug Repurposing for Treating NCOR-Related Intellectual Disability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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1,049 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Catherine LordCenter for Autism and the Developing Brain, NewYork-Presbyterian Hospital, Weill Cornell Medicine, Cornell University, White Plains, NY, USA. Electronic address: cal2028@med.cornell.edu.
Mayada ElsabbaghDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Gillian BairdEvelina Children's Hospital, King's Health Partners, London, UK.
Jeremy Veenstra-VanderweeleDivision of Child and Adolescent Psychiatry, Center for Autism and the Developing Brain, NewYork-Presbyterian Hospital, Department of Psychiatry, Columbia University, New York State Psychiatric Institute, White Plains, NY, USA.

Funding

Mobilizing Community Systems to Engage Families in Early ASD Detection & ServicesR01MH104423 · NIMH · FLORIDA STATE UNIVERSITY · PI KLIN, AMI, LORD, CATHERINE · 2014 to 2018
$10.4M
Transitioning to Adulthood: A Prospective Longitudinal StudyR01HD081199 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORD, CATHERINE · 2015 to 2019
$3.1M
NICHD NIH HHS R01 HD081199NIMH NIH HHS R01 MH104423
6 · The paper itself

Abstract

Autism spectrum disorder is a term used to describe a constellation of early-appearing social communication deficits and repetitive sensory-motor behaviours associated with a strong genetic component as well as other causes. The outlook for many individuals with autism spectrum disorder today is brighter than it was 50 years ago; more people with the condition are able to speak, read, and live in the community rather than in institutions, and some will be largely free from symptoms of the disorder by adulthood. Nevertheless, most individuals will not work full-time or live independently. Genetics and neuroscience have identified intriguing patterns of risk, but without much practical benefit yet. Considerable work is still needed to understand how and when behavioural and medical treatments can be effective, and for which children, including those with substantial comorbidities. It is also important to implement what we already know and develop services for adults with autism spectrum disorder. Clinicians can make a difference by providing timely and individualised help to families navigating referrals and access to community support systems, by providing accurate information despite often unfiltered media input, and by anticipating transitions such as family changes and school entry and leaving.

Indexed as

AdolescentAdultAutism Spectrum DisorderChildHumansRisk Factors

Identifiers

PMID30078460
PMCPMC7398158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.