ReviewJournal of cell communication and signaling2018
Vasa vasorum inside out/outside in communication: a potential role in the patency of saphenous vein coronary artery bypass grafts.
Review in Journal of cell communication and signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Influence of Three Different Surgical Techniques on Microscopic Damage of Saphenous Vein Grafts-A Randomized Study.Medicina (Kaunas, Lithuania) · 2023Trial
- In vivo three-dimensional FD-OCT visualization of microvascular structures consistent with vasa vasorum in a conventionally harvested saphenous vein graft.General thoracic and cardiovascular surgery cases · 2026Article
- Increased vein wall thickness in Behçet's disease: from intravascular mechanical stress to vascular remodelling and venous thrombosis.Rheumatology international · 2026Review
- Role of Perivascular Adipose Tissue in Vein Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Vasa vasorum of the no-touch saphenous vein graft observed using frequency-domain optical coherence tomography.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- The intricate cellular ecosystem of human peripheral veins as revealed by single-cell transcriptomic analysis.PloS one · 2024Article
- Vasa Vasorum in Saphenous Vein for CABG: A Review of Morphological Characteristics.Brazilian journal of cardiovascular surgery · 2023Review
- Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia.International journal of molecular sciences · 2022Article
- The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease.Cells · 2022Review
- On vasa vasorum: A history of advances in understanding the vessels of vessels.Science advances · 2022Review
- A modified no-touch technique for anastomosis to create a radiocephalic arteriovenous fistula.Journal of vascular surgery cases and innovative techniques · 2021Article
- Saphenous veins in coronary artery bypass grafting need external support.Asian cardiovascular & thoracic annals · 2021Review
- What is the impact of preserving the endothelium on saphenous vein graft performance? Comments on the 'NO' touch harvesting technique.Journal of cardiothoracic surgery · 2021Article
- A Brief Comment on Vasa Vasorum of Human Saphenous Vein: relevance for Coronary Artery Bypass Surgery.Brazilian journal of cardiovascular surgery · 2021Review
- Saphenous Vein Vasa Vasorum as a Potential Target for Perivascular Fat-Derived Factors.Brazilian journal of cardiovascular surgery · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The saphenous vein (SV) is the most commonly used conduit for revascularization in patients undergoing coronary artery bypass surgery (CABG). The patency rate of this vessel is inferior to the internal thoracic artery (ITA). In the majority of CABG procedures the ITA is removed with its outer pedicle intact whereas the (human) SV (hSV) is harvested with pedicle removed. The vasa vasorum, a microvessel network providing the adventitia and media with oxygen and nutrients, is more pronounced and penetrates deeper towards the lumen in veins than in arteries. When prepared in conventional CABG the vascular trauma caused when removing the hSV pedicle damages the vasa vasorum, a situation affecting transmural flow potentially impacting on graft performance. In patients, where the hSV is harvested with pedicle intact, the vasa vasorum is preserved and transmural blood flow restored at graft insertion and completion of CABG. By maintaining blood supply to the hSV wall, apart from oxygen and nutrients, the vasa vasorum may also transport factors potentially beneficial to graft performance. Studies, using either corrosion casts or India ink, have shown the course of vasa vasorum in animal SV as well as in hSV. In addition, there is some evidence that vasa vasorum of hSV terminate in the vessel lumen based on ex vivo perfusion, histological and ultrastructural studies. This review describes the preparation of the hSV as a bypass conduit in CABG and its performance compared with the ITA as well as how and why its patency might be improved by harvesting with minimal trauma in a way that preserves an intact vasa vasorum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.