Evidence map›Paper›PMID 30077720›Full record

ArticleEBioMedicine2018

Extracellular Vesicles Secreted by Human Adipose-derived Stem Cells (hASCs) Improve Survival Rate of Rats with Acute Liver Failure by Releasing lncRNA H19.

Yinpeng Jin, Junyi Wang, Hongchao Li, Shane Gao, Rongfeng Shi, Danjing Yang, Xianli Wang, Xi Wang, Liang Zhu, Xiaojin Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. [Research progress on the mechanisms and optimization strategies of mesenchymal stem cell-derived exosomes in the treatment of liver diseases].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yinpeng JinShanghai Public Health Clinical Center, Fudan University, Jinshan, Shanghai 201508, PR China. Electronic address: 1182008211@qq.com.
Junyi WangShanghai Liver Diseases Research Center, The 85th Hospital of PLA, Shanghai 200235, PR China.
Hongchao LiShanghai Liver Diseases Research Center, The 85th Hospital of PLA, Shanghai 200235, PR China.
Shane GaoEast Hospital, Tongji University School of Medicine, Shanghai 200120, PR China.
Rongfeng ShiDepartment of Interventional & Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, PR China.
Danjing YangEast Hospital, Tongji University School of Medicine, Shanghai 200120, PR China.
Xianli WangInstitute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, PR China.
Xi WangShanghai Public Health Clinical Center, Fudan University, Jinshan, Shanghai 201508, PR China.
Liang ZhuEast Hospital, Tongji University School of Medicine, Shanghai 200120, PR China.
Xiaojin WangShanghai Liver Diseases Research Center, The 85th Hospital of PLA, Shanghai 200235, PR China.
Chengwei ChenShanghai Liver Diseases Research Center, The 85th Hospital of PLA, Shanghai 200235, PR China.
Ke NingDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
Zhengliang GaoEast Hospital, Tongji University School of Medicine, Shanghai 200120, PR China. Electronic address: zhengliang_gao@tongji.edu.cn.
Jun XuEast Hospital, Tongji University School of Medicine, Shanghai 200120, PR China. Electronic address: xunymc2000@yahoo.com.
Qingchun FuShanghai Public Health Clinical Center, Fudan University, Jinshan, Shanghai 201508, PR China. Electronic address: qufu85@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has previously been reported that human adipose-derived stem cells (hASCs) can promote the regeneration of damaged tissues in rats with liver failure through a 'paracrine effect'. Here we demonstrate a therapeutic effect of hASCs derived Extracellular Vesicles (EVs) on rat models with acute liver failure, as shown by the improvement of the survival rate by >70% compared to controls. Gene sequencing of rat liver revealed an increase in human long-chain non-coding RNA (lncRNA) H19 after hASC-derived EVs transplantation. When the H19 coding sequence was silenced in hASCs and EVs were then collected for treatment of rats with liver failure, we saw a decrease in the survival rate to 40%, compared to treatment with EVs generated from non-silenced hASCs. These data indicate that lncRNA H19 may be a potential therapeutic target for the treatment of liver failure.

Indexed as

Adipose TissueAnimalsExtracellular VesiclesHumansLiver Failure, AcuteMaleRats, Sprague-DawleyRegenerationRNA, Long NoncodingStem CellsH19 long non-coding RNARNA, Long NoncodingAdipose-derived stem cellsExtracellular vesiclesLiver failureLncRNARegeneration

Identifiers

PMID30077720
PMCPMC6116414

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.