Evidence map›Paper›PMID 30077487›Full record

ReviewBurns : journal of the International Society for Burn Injuries2018

Bone metabolism in pediatric burned patients: A review.

Eric Schryver, Gordon L Klein, David N Herndon, Oscar E Suman, Ludwik K Branski, Linda E Sousse

Open access · greenAbstract readReview
In one paragraph

Review in Burns : journal of the International Society for Burn Injuries, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Musculoskeletal Issues in Pediatric Burn Patients.Seminars in plastic surgery · 2024
    Review
  7. Review
  8. Review
  9. Article
  10. [Changes in the related indicators of bone formation and bone resorption in severely burned rats].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Eric SchryverShriners Hospital for Children(®)-Galveston, University of Texas Medical Branch, Galveston, TX 77555, USA.
Gordon L KleinShriners Hospital for Children(®)-Galveston, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Orthopedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, TX 77555, USA.
David N HerndonShriners Hospital for Children(®)-Galveston, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.
Oscar E SumanShriners Hospital for Children(®)-Galveston, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
Ludwik K BranskiShriners Hospital for Children(®)-Galveston, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
Linda E SousseShriners Hospital for Children(®)-Galveston, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: lesousse@utmb.edu.
Shriners Hospitals for Children - Galveston · US

Funding

Project 9: The role of androgen/corticosteroid in fat, muscle and glucose metabolism of burn victimsP50GM060338 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SZABO, CSABA · 2000 to 2017
$24.2M
MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSER01GM056687 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI HERNDON, DAVID N. · 1998 to 2017
$9.0M
Oxandrolone and Exercise: A potent therapy in the rehabilitation from burnsR01HD049471 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUMAN-VEJAS, OSCAR E. · 2006 to 2019
$5.8M
NCCDPHP CDC HHS U48 DP000043NICHD NIH HHS R01 HD049471NIGMS NIH HHS P50 GM060338NIGMS NIH HHS R01 GM056687
6 · The paper itself

Abstract

Severe burns in children can lead to growth delays, bone loss, and wasting of lean body mass and muscle with subsequent long-term effects such as osteoporosis. The following review examines 11 randomized, placebo-controlled, prospective clinical trials in pediatric burns between 1995 and 2017. These studies included approximately 250 burned children, and they were conducted to evaluate the impact of severe burn on markers of bone formation and bone metabolism. Some trials also analyzed current therapy regimens such as pamidronate and vitamin D. The clinical utility of these outlined biomarkers is uncertain with regard to acute burn care, as the current literature remains unclear. This review thus serves to address the impact of severe burn on markers of bone formation and bone metabolism in pediatric patients but will not focus on the clinical utility of the markers. The aim of this review is to summarize the findings of the trials to guide the future care of burned patients to maximize bone recovery.

Indexed as

Bone RemodelingOsteogenesisAdaptor Proteins, Signal TransducingAluminumBody CompositionBone and BonesBone DensityBone Density Conservation AgentsBone Morphogenetic Protein 2Bone Morphogenetic ProteinsBurnsCalciumChildCollagen Type ICopperGenetic Markers25-hydroxyvitamin DAdaptor Proteins, Signal TransducingAluminumBone Density Conservation AgentsBone Morphogenetic Protein 2Bone Morphogenetic ProteinsCalciumCollagen Type ICopperGenetic MarkersGlucocorticoidsMagnesiumOsteocalcinPamidronateParathyroid HormoneSOST protein, humanVitamin DZincAluminumBone metabolismBone morphogenetic protein-2BurnsCalciumOsteocalcinParathyroid hormoneSclerostinType I collagenUrine free cortisolVitamin D

Identifiers

PMID30077487
PMCPMC9810107
OpenAlexW2887415233

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.