Evidence map›Paper›PMID 30077203›Full record

ArticleMayo Clinic proceedings2018

Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet.

David A Muñiz Pedrogo, Michael D Jensen, Carol T Van Dyke, Joseph A Murray, Jeffrey A Woods, Jun Chen, Purna C Kashyap, Vandana Nehra

Erratum issuedAbstract read
In one paragraph

Article in Mayo Clinic proceedings, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Modulatory Effects ofNutrients · 2026
    Article
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  9. Article
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  13. Impacts of non-nutritive sweeteners on the human microbiome.Immunometabolism (Cobham, Surrey) · 2025
    Review
  14. Article
  15. Article
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  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

David A Muñiz PedrogoCenter for Clinical and Translational Science, Mayo Clinic, Rochester, MN; University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
Michael D JensenDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN.
Carol T Van DykeDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
Joseph A MurrayDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
Jeffrey A WoodsCenter on Health, Aging, and Disability, University of Illinois at Urbana-Champaign, Champaign, IL.
Jun ChenDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
Purna C KashyapDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN. Electronic address: kashyap.purna@mayo.edu.
Vandana NehraDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
Mayo Clinic in Arizona · USMayo Clinic in Florida · USUniversity of Illinois Urbana-Champaign · USUniversity of Puerto Rico System · PR

Funding

Mechanisms of alteration of GI physiology by gut microbesR01DK114007 · NIDDK · MAYO CLINIC ROCHESTER · PI Purna C Kashyap · 2017 to 2026
$4.7M
MECHANISMS OF ALTERATION OF GASTROINTESTINAL MOTILITY BY GUT MICROBIOTAK08DK100638 · NIDDK · MAYO CLINIC ROCHESTER · PI KASHYAP, PURNA C · 2014 to 2017
$610k
Mechanisms of alteration of gastrointestinal physiology by gut microbesR03DK111850 · NIDDK · MAYO CLINIC ROCHESTER · PI KASHYAP, PURNA C · 2017 to 2018
$159k
NIDDK NIH HHS K08 DK100638NIDDK NIH HHS R01 DK114007NIDDK NIH HHS R03 DK111850
6 · The paper itself

Abstract

The rising incidence of obesity requires the reevaluation of our current therapeutic strategies to optimize patient outcomes. The objective of this study was to determine whether compositional and functional characteristics of the gut microbiota in adults predict responses to a comprehensive lifestyle intervention program in overweight and obese adults. We recruited 26 participants from the Mayo Clinic Obesity Treatment Research Program between August 6, 2013, and September 12, 2013, to participate in a lifestyle intervention program for weight loss. Adults aged 18 to 65 years with a body mass index of 27 to 39.9 kg/m

Indexed as

Carbohydrate MetabolismGastrointestinal MicrobiomeWeight LossWeight Reduction ProgramsAdultFecesFemaleGlycoside HydrolasesGlycosyltransferasesHumansMaleMiddle AgedOverweightTransposasesGlycoside HydrolasesGlycosyltransferasesTransposases

Identifiers

PMID30077203
PMCPMC6107068
OpenAlexW2885712707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.