ArticleBiomaterials2018
A biodegradable synthetic graft for small arteries matches the performance of autologous vein in rat carotid arteries.
Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- An overview of recent flexible- and soft-biomaterial applications in myocardial infarction and other cardiovascular diseases.Materials today. Bio · 2026Review
- A Dual-Crosslinked Metallo-elastomer Platform for Architecture-Directed Vascular Remodeling.Advanced fiber materials · 2026Article
- Synthetic and Tissue-Engineered Vascular Grafts: Current Status, Emerging Technologies, and Clinical Prospects.Reviews in cardiovascular medicine · 2025Review
- Biodegradable Synthetic Graft with Sustained Hydrogen Sulfide Release Promotes Endothelial Cell Growth.Macromolecular bioscience · 2025Article
- Photocurable and 3D Printable Functional Polyesters to Engineer Elastomeric Scaffolds for Biomedical Applications.Macromolecular bioscience · 2025Article
- Fabrication and characterization of electrospun polycaprolactone/RSC advances · 2025Article
- Effect of Collagen Fiber Tortuosity Distribution on the Mechanical Response of Arterial Tissues.Journal of biomechanical engineering · 2025Article
- The tooth transformer® revolution: autologous dentin biomaterials and platelet concentrates in oral regeneration. A parallel narrative systematic review.Frontiers in dental medicine · 2025Review
- Construction of vascular grafts based on tissue-engineered scaffolds.Materials today. Bio · 2024Review
- Polyglycerol Sebacate Elastomer: A Critical Overview of Synthetic Methods and Characterisation Techniques.Polymers · 2024Review
- Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Pair of Functional Polyesters That Are Photo-Cross-Linkable and Electrospinnable to Engineer Elastomeric Scaffolds with Tunable Structure and Properties.ACS applied bio materials · 2024Article
- A bioactive compliant vascular graft modulates macrophage polarization and maintains patency with robust vascular remodeling.Bioactive materials · 2023Article
- Tween-80 improves single/coaxial electrospinning of three-layered bioartificial blood vessel.Journal of materials science. Materials in medicine · 2022Article
- Review
- Pharmacological manipulation of macrophage autophagy effectively rejuvenates the regenerative potential of biodegrading vascular graft in aging body.Bioactive materials · 2022Article
- Article
- Human iPS Cell-derived Tissue Engineered Vascular Graft: Recent Advances and Future Directions.Stem cell reviews and reports · 2021Review
- Poly(Glycerol Sebacate) in Biomedical Applications-A Review of the Recent Literature.Advanced healthcare materials · 2021Review
- Electrospun Tissue-Engineered Arterial Graft Thickness Affects Long-Term Composition and Mechanics.Tissue engineering. Part A · 2021Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Autologous veins are the most widely used grafts for bypassing small arteries in coronary and peripheral arterial occlusive diseases. However, they have limited availability and cause donor-site morbidity. Here, we report a direct comparison of acellular biodegradable synthetic grafts and autologous veins as interposition grafts of rat carotid arteries, which is a good model for clinically relevant small arteries. Notably, extensive but transient infiltration of circulating monocytes at day 14 in synthetic grafts leads to a quickly-resolved inflammation and arterial-like tissue remodeling. The vein graft exhibits a similar inflammation phase except the prolonged presence of inflammatory monocytes. The walls of the remodeled synthetic graft contain many circumferentially aligned contractile non-proliferative smooth muscle cells (SMCs), collagen and elastin. In contrast, the walls of the vein grafts contain disorganized proliferating SMCs and thicken over time, suggesting the onset of stenosis. At 3 months, both grafts have a similar patency, extracellular matrix composition, and mechanical properties. Furthermore, synthetic grafts exhibit recruitment and re-orientation of newly synthesized collagen fibers upon mechanical loading. To our knowledge, this is the first demonstration of a biodegradable synthetic vascular graft with a performance similar to an autologous vein in small artery grafting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.