Evidence map›Paper›PMID 30076926›Full record

ArticleThe Journal of investigative dermatology2019

MicroRNA-211 Loss Promotes Metabolic Vulnerability and BRAF Inhibitor Sensitivity in Melanoma.

Anupama Sahoo, Sanjaya K Sahoo, Piyush Joshi, Bongyong Lee, Ranjan J Perera

Abstract read
In one paragraph

Article in The Journal of investigative dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

  1. Omics in Cutaneous Melanoma.Asian Pacific journal of cancer prevention : APJCP · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anupama SahooSanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, USA.
Sanjaya K SahooSanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, USA.
Piyush JoshiSanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, USA; Johns Hopkins School of Medicine, Department of Oncology, St. Petersburg, Florida, USA.
Bongyong LeeSanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, USA; Johns Hopkins School of Medicine, Department of Oncology, St. Petersburg, Florida, USA.
Ranjan J PereraSanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, USA; Johns Hopkins School of Medicine, Department of Oncology, St. Petersburg, Florida, USA. Electronic address: Jperera2@jhmi.edu.
Sanford Burnham Prebys Medical Discovery Institute · US

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2M
Identification of the molecular mechanism of miR-211 and its target genes in melanocytes and pigmented melanoma senescence and apoptosisR21CA202197 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI PERERA, RANJAN JOSEPH · 2016 to 2017
$467k
Identification and characterization of long noncoding RNAs in human melanomasR03CA165184 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI PERERA, RANJAN JOSEPH · 2012 to 2013
$189k
NCI NIH HHS P30 CA030199NCI NIH HHS R03 CA165184NCI NIH HHS R21 CA202197
6 · The paper itself

Abstract

The clinical management of malignant melanoma remains a challenge because these tumors are intrinsically aggressive and prone to therapeutic resistance. MicroRNA (miR)-211 is an emerging melanoma oncogene. Melanoma metabolism adapts to promote survival, including in response to BRAF

Indexed as

MutationAntineoplastic AgentsCell Line, TumorDNA Mutational AnalysisDNA, NeoplasmHumansMelanomaMicroRNAsProto-Oncogene Proteins B-rafSignal TransductionSkin NeoplasmsVemurafenibAntineoplastic AgentsBRAF protein, humanDNA, NeoplasmMicroRNAsMIRN211 microRNA, humanProto-Oncogene Proteins B-rafVemurafenib

Identifiers

PMID30076926
PMCPMC6309654
OpenAlexW2885873542

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.