Evidence map›Paper›PMID 30076783›Full record

ArticleClinical and experimental immunology2018

Altered CD4

G Elias, A Souquette, S Heynderickx, I De Meester, H Jansens, P Beutels, P Van Damme, E Smits, P G Thomas, V Van Tendeloo and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Multivariate Host-Pathogen Interactions Driving Heterogeneous Viral Shedding and CD8medRxiv : the preprint server for health sciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

G EliasLaboratory of Experimental Haematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.
A SouquetteDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
S HeynderickxLaboratory of Experimental Haematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.
I De MeesterLaboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.
H JansensDepartment of Microbiology, Antwerp University Hospital, University of Antwerp, Edegem (Antwerp), Belgium.
P BeutelsCentre for Health Economics Research and Modeling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
P Van DammeAntwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), University of Antwerp, Antwerp, Belgium.
E SmitsLaboratory of Experimental Haematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.
P G ThomasDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
V Van TendelooLaboratory of Experimental Haematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.
B OgunjimiLaboratory of Experimental Haematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.
University of Antwerp · BESt. Jude Children's Research Hospital · USAntwerp University Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogen exposure, including but not limited to herpesviruses, moulds the shape of the immune system, both at a basal state and in response to immune challenge. However, little is known about the impact of high exposure to other viruses on baseline immune signatures and how the immune system copes with repetitive exposures to maintain a balanced functionality. Here we investigated baseline immune signatures, including detailed T cell phenotyping, antigen-specific CD4

Indexed as

NursesAdultCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCellular SenescenceCytokinesCytomegalovirusCytomegalovirus InfectionsFemaleHerpesvirus 3, HumanHumansImmediate-Early ProteinsImmune SystemImmunity, CellularImmunophenotypingCytokinesglycoprotein E, varicella-zoster virusIE62 protein, Human herpesvirus 3Immediate-Early ProteinsTrans-ActivatorsViral Envelope Proteinscytomegalovirusimmune signaturesimmunosenescenceT cellvaricella zoster virus

Identifiers

PMID30076783
PMCPMC6194343
OpenAlexW2887172478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.