Observational studyHuman brain mapping2018
Structural network topology correlates of microstructural brain dysmaturation in term infants with congenital heart disease.
Observational study in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- MRI-DTI contributes to evaluating diffuse neural injury following repetitive mild traumatic brain injury.iScience · 2025Article
- Streamline tractography of the fetal brain in utero with machine learning.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Altered Connectome Topology in Newborns at Risk for Cognitive Developmental Delay: A Cross-Etiologic Study.Human brain mapping · 2025Article
- Disrupted White Matter Topology Organization in Preschool Children with Tetralogy of Fallot.Brain and behavior · 2024Article
- The cumulative impact of clinical risk on brain networks and associations with executive function impairments in adolescents with congenital heart disease.Human brain mapping · 2024Article
- Article
- Characterizing normal perinatal development of the human brain structural connectivity.Human brain mapping · 2024Article
- Cerebral Spinal Fluid Volumetrics and Paralimbic Predictors of Executive Dysfunction in Congenital Heart Disease: A Machine Learning Approach Informing Mechanistic Insights.medRxiv : the preprint server for health sciences · 2023Article
- Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note.Journal of cardiovascular development and disease · 2023Article
- Increased Cerebello-Prefrontal Connectivity Predicts Poor Executive Function in Congenital Heart Disease.Journal of clinical medicine · 2023Article
- Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study.Diagnostics (Basel, Switzerland) · 2023Article
- Biological and structural phenotypes associated with neurodevelopmental outcomes in congenital heart disease.Translational pediatrics · 2023Review
- Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study.medRxiv : the preprint server for health sciences · 2023Article
- Altered white matter connectivity in children with congenital heart disease with single ventricle physiology.Scientific reports · 2023Article
- A pilot study: Comparing a novel noninvasive measure of cerebrovascular stability index with an invasive measure of cerebral autoregulation in neonates with congenital heart disease.Journal of clinical and translational science · 2023Article
- Association of Cerebrovascular Stability Index and Head Circumference Between Infants With and Without Congenital Heart Disease.Pediatric cardiology · 2022Article
- Harmonization of Multi-Center Diffusion Tensor Tractography in Neonates with Congenital Heart Disease: Optimizing Post-Processing and Application of ComBat.Neuroimage. Reports · 2022Article
- Reduced Cerebellar Volume in Term Infants with Complex Congenital Heart Disease: Correlation with Postnatal Growth Measurements.Diagnostics (Basel, Switzerland) · 2022Article
- Neonatal brain injury influences structural connectivity and childhood functional outcomes.PloS one · 2022Article
- Clinical factors associated with microstructural connectome related brain dysmaturation in term neonates with congenital heart disease.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Neonates with complex congenital heart disease (CHD) demonstrate microstructural brain dysmaturation, but the relationship with structural network topology is unknown. We performed diffusion tensor imaging (DTI) in term neonates with CHD preoperatively (N = 61) and postoperatively (N = 50) compared with healthy term controls (N = 91). We used network topology (graph) analyses incorporating different weighted and unweighted approaches and subject-specific white matter segmentation to investigate structural topology differences, as well as a voxel-based analysis (VBA) to confirm the presence of microstructural dysmaturation. We demonstrate cost-dependent network inefficiencies in neonatal CHD in the pre- and postoperative period compared with controls, related to microstructural differences. Controlling for cost, we show the presence of increased small-worldness (hierarchical fiber organization) in CHD infants preoperatively, that persists in the postoperative period compared with controls, suggesting the early presence of brain reorganization. Taken together, topological microstructural dysmaturation in CHD infants is accompanied by hierarchical fiber organization during a protracted critical period of early brain development. Our methodology also provides a pipeline for quantitation of network topology changes in neonates and infants with microstructural brain dysmaturation at risk for perinatal brain injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.