ArticleHuman brain mapping2018
Altered neural signatures of interoception in multiple sclerosis.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Heartbeat-Evoked Responses in M/EEG: A Systematic Review of Methods With Suggestions for Analysis and Reporting.Psychophysiology · 2026Pooled it
- Disrupted and reorganized connectivity of brain networks in multiple sclerosis: a systematic review and meta-analysis of resting-state functional MRI.Journal of neurology · 2026Pooled it
- Neuroimaging Meta-Analyses Reveal Convergence of Interoception, Emotion, and Social Cognition Across Neurodegenerative Diseases.Biological psychiatry · 2025Pooled it
- Functional connectivity modifications in monoaminergic circuits occur in fatigued MS patients treated with fampridine and amantadine.Journal of neurology · 2023Trial
- Shedding Light on Interaction Between Neurological Symptoms and Psychiatric Episodes in Multiple Sclerosis: Novel Hypothesis and Therapeutic Avenues.Molecular neurobiology · 2026Review
- Heartbeat-evoked potentials reveal interoceptive dysfunction in clinical disorders: Experimental frameworks and promising applications.Psychological medicine · 2026Review
- Functional Connectivity Alterations of the Central Autonomic Network in Multiple Sclerosis: Links to Fatigue and Aerobic Training Effects.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Interoceptive and metacognitive contributors to fatigue in multiple sclerosis: network and mediation analyses.Acta neurologica Belgica · 2026Article
- Bodily experiences in multiple sclerosis: functional neurological symptoms, body image dissatisfaction, and disordered eating behaviors. A narrative review.Frontiers in psychology · 2026Review
- Characterizing the Heartbeat-Evoked Potential: A Two-Component Model of Cardiac Signal Processing?Psychophysiology · 2025Article
- White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis.Scientific reports · 2025Article
- Neural Interoceptive Processing Is Modulated by Deep Brain Stimulation to Subcallosal Cingulate Cortex for Treatment-Resistant Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Impaired interoception in Colombian victims of armed conflict with PTSD: a preliminary HEP study.Frontiers in psychology · 2025Article
- A synergetic turn in cognitive neuroscience of brain diseases.Trends in cognitive sciences · 2024Review
- Intrinsic timescales and predictive allostatic interoception in brain health and disease.Neuroscience and biobehavioral reviews · 2024Review
- The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds.Scientific data · 2023Article
- Reduced Heartbeat-Evoked Responses in a Near-Death Case Report.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Temporal Irreversibility of Large-Scale Brain Dynamics in Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed to determine whether MS patients present changes in interoception-that is, the monitoring of autonomic bodily information-a process that might be related to various bodily dysfunctions. We performed two studies in 34 relapsing-remitting, early-stage MS patients and 46 controls matched for gender, age, and education. In Study 1, we evaluated the heartbeat-evoked potential (HEP), a cortical signature of interoception, via a 128-channel EEG system during a heartbeat detection task including an exteroceptive and an interoceptive condition. Then, we obtained whole-brain MRI recordings. In Study 2, participants underwent fMRI recordings during two resting-state conditions: mind wandering and interoception. In Study 1, controls exhibited greater HEP modulation during the interoceptive condition than the exteroceptive one, but no systematic differences between conditions emerged in MS patients. Patients presented atrophy in the left insula, the posterior part of the right insula, and the right anterior cingulate cortex, with abnormal associations between neurophysiological and neuroanatomical patterns. In Study 2, controls showed higher functional connectivity and degree for the interoceptive state compared with mind wandering; however, this pattern was absent in patients, who nonetheless presented greater connectivity and degree than controls during mind wandering. MS patients were characterized by atypical multimodal brain signatures of interoception. This finding opens a new agenda to examine the role of inner-signal monitoring in the body symptomatology of MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.