ArticleRapid communications in mass spectrometry : RCM2018
A novel laser desorption/ionization method using through hole porous alumina membranes.
Article in Rapid communications in mass spectrometry : RCM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Recent progress in nanomaterial-enhanced SALDI-MSI for spatial metabolomics.Analytical and bioanalytical chemistry · 2026Review
- AlRSC advances · 2026Article
- Nanostructure-Dependent Signal Intensity in Through-Hole Porous Alumina Membranes for Mass Spectrometry Imaging.Rapid communications in mass spectrometry : RCM · 2026Article
- Review
- Mass Spectrometry Imaging.Mass spectrometry (Tokyo, Japan) · 2022Article
- Matrix-Free High-Resolution Atmospheric-Pressure SALDI Mass Spectrometry Imaging of Biological Samples Using Nanostructured DIUTHAME Membranes.Metabolites · 2021Article
- Novel Blotting Method for Mass Spectrometry Imaging of Metabolites in Strawberry Fruit by Desorption/Ionization Using Through Hole Alumina Membrane.Foods (Basel, Switzerland) · 2020Article
- A novel laser desorption/ionization method using through hole porous alumina membranes.Rapid communications in mass spectrometry : RCM · 2018Article
- Degradation strategies for structural characterization of insoluble synthetic polymers by mass spectrometry.Mass spectrometry reviewsReview
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Authors and funding
3 authors.
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Abstract
rationaleA novel matrix-free laser desorption/ionization method based on porous alumina membranes was developed. The porous alumina membranes have a two-dimensional (2D) ordered structure consisting of closely aligned straight through holes of sub-micron in diameter that are amenable to mass production by industrial fabrication processes.
methodsConsidering a balance between the ion generating efficiency and the mechanical strength of the membranes, the typical values for the hole diameter, open aperture ratio and membrane thickness were set to 200 nm, 50% and 5 μm, respectively. The membranes were coated with platinum on a single side that was exposed to the laser. Evaluation experiments were conducted on the feasibility of this membrane structure for an ionization method using a single peptide and mixed peptides and polyethylene glycol samples and a commercial matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometer in the positive ion mode.
resultsResults showed a softness of ionization and no sweet spot nature. The capillary action of the through holes with very high aspect ratio enables several loading protocols including sample impregnation from the surface opposite to the laser exposure side.
conclusionsThe feasibility study indicates that the through hole porous alumina membranes have several advantages in terms of usefulness over the conventional surface-assisted laser desorption ionization (SALDI) methods. The proposed novel ionization method is termed Desorption Ionization Using Through Hole Alumina Membrane (DIUTHAME).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.