Evidence map›Paper›PMID 30076495›Full record

ArticleEuropean journal of epidemiology2018

Shift work and risk of incident dementia: a study of two population-based cohorts.

Kathleen Bokenberger, Arvid Sjölander, Anna K Dahl Aslan, Ida K Karlsson, Torbjörn Åkerstedt, Nancy L Pedersen

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  8. Circadian clock disruption promotes retinal photoreceptor degeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kathleen BokenbergerDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177, Stockholm, Sweden. kathleen.bokenberger@ki.se.ORCID http://orcid.org/0000-0001-9127-2818
Arvid SjölanderDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177, Stockholm, Sweden.
Anna K Dahl AslanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177, Stockholm, Sweden.
Ida K KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177, Stockholm, Sweden.
Torbjörn ÅkerstedtStress Research Institute, Stockholm University, 10691, Stockholm, Sweden.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177, Stockholm, Sweden.

Funding

DEMENTIA IN TWINSR01AG008724 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET · 1990 to 2002
$1.4M
NIA NIH HHS R01 AG008724NIA NIH HHS R01-AG08724Nordic Program on Health and Welfare 74809Swedish Research Council for Health, Working Life and Welfare 2013-08689Swedish Research Council for Health, Working Life and Welfare 2013-2292
6 · The paper itself

Abstract

This study aimed to investigate the association between shift work and incident dementia in two population-based cohorts from the Swedish Twin Registry (STR). The STR-1973 sample included 13,283 participants born 1926-1943 who received a mailed questionnaire in 1973 that asked about status (ever/never) and duration (years) of shift work employment. The Screening Across the Lifespan Twin (SALT) sample included 41,199 participants born 1900-1958 who participated in a telephone interview in 1998-2002 that asked about night work status and duration. Dementia diagnoses came from Swedish patient registers. Cox proportional-hazards regression was used to estimate hazard ratios (HR) with 95% confidence intervals (CI). Potential confounders such as age, sex, education, diabetes, cardiovascular disease and stroke were included in adjusted models. In genotyped subsamples (n = 2977 in STR-1973; n = 10,366 in SALT), APOE ε4 status was considered in models. A total of 983 (7.4%) and 1979 (4.8%) dementia cases were identified after a median of 41.2 and 14.1 years follow-up in the STR-1973 and SALT sample, respectively. Ever shift work (HR 1.36, 95% CI 1.15-1.60) and night work (HR 1.12, 95% CI 1.01-1.23) were associated with higher dementia incidence. Modest dose-response associations were observed, where longer duration shift work and night work predicted increased dementia risk. Among APOE ε4 carriers, individuals exposed to ≥ 20 years of shift work and night work had increased dementia risk compared to day workers. Findings indicate that shift work, including night shift work, compared to non-shift jobs is associated with increased dementia incidence. Confirmation of findings is needed.

Indexed as

AgedAged, 80 and overCohort StudiesDementiaFemaleHumansIncidenceMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsShift Work ScheduleSurveys and QuestionnairesSwedenTime FactorsDementia incidenceEpidemiologyNight shift workProspective cohortShift work

Identifiers

PMID30076495
PMCPMC6153510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.