Evidence map›Paper›PMID 30076463›Full record

ReviewHistochemistry and cell biology2018

Perichromatin region: a moveable feast.

Irene Masiello, Stella Siciliani, Marco Biggiogera

Abstract readReview
PubMed Publisher
In one paragraph

Review in Histochemistry and cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Resolving Sub-Nuclear Architecture from Compartments to Functional Domains.International journal of molecular sciences · 2026
    Review
  2. Basic Epigenetic Mechanisms.Sub-cellular biochemistry · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Evidence for Tethering of Human Cytomegalovirus Genomes to Host Chromosomes.Frontiers in cellular and infection microbiology · 2020
    Article
  8. Article
  9. In focus in HCB.Histochemistry and cell biology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Irene MasielloDepartment of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100, Pavia, Italy.
Stella SicilianiDepartment of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100, Pavia, Italy.
Marco BiggiogeraDepartment of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100, Pavia, Italy. marco.biggiogera@unipv.it.ORCID http://orcid.org/0000-0003-3834-6712

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The perichromatin region is an elusive zone of the cell nucleus located at the periphery of the condensed chromatin areas. This region is visible at the electron microscope level under special staining treatments, otherwise it is merged with the border of condensed chromatin. In this 200 nm-thick area, several fundamental cell processes take place, such as replication, DNA repair and transcription. In addition, RNA processing occurs in the perichromatin region, including 5'-capping and 3'-polyadenylation as well as splicing. Recently, it has become clear that also some epigenetics modifications take place there, such as methylation of DNA and RNA on cytosine and adenosine. In summary, this thin interface between chromatin and the interchromatinic space represents the zone where the majority of the functions of DNA in interphase occur, in a place where there is no steric hindrance of condensed chromatin, the products can easily move away toward their target and the enzymes can freely dock.

Indexed as

AnimalsCell NucleusChromatinDNAHumansRNAChromatinDNARNACell nucleusDNA repairElectron microscopyPerichromatin regionReplicationTranscription

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.