Evidence map›Paper›PMID 30076401›Full record

Observational studyJournal of perinatology : official journal of the California Perinatal Association2018

Higher intake of coagulase-negative staphylococci from maternal milk promotes gut colonization with mecA-negative Staphylococcus epidermidis in preterm neonates.

Hiie Soeorg, Sirli Treumuth, Hanna Kadri Metsvaht, Imbi Eelmäe, Mirjam Merila, Mari-Liis Ilmoja, Irja Lutsar, Tuuli Metsvaht

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Look Who's Talking: Host and Pathogen Drivers ofInternational journal of molecular sciences · 2022
    Review
  3. Genetic relatedness of Gram-negative bacteria colonizing gut and skin of neonates and mother's own milk.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hiie SoeorgDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia. hiie.soeorg@ut.ee.
Sirli TreumuthDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Hanna Kadri MetsvahtDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Imbi EelmäePaediatric Intensive Care Unit, Clinic of Anaesthesiology and Intensive Care, Tartu University Hospital, Tartu, Estonia.
Mirjam MerilaNeonatal Unit, Children's Clinic, Tartu University Hospital, Tartu, Estonia.
Mari-Liis IlmojaDepartment of Anaesthesiology and Intensive Care, Tallinn Children's Hospital, Tallinn, Estonia.
Irja LutsarDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Tuuli MetsvahtPaediatric Intensive Care Unit, Clinic of Anaesthesiology and Intensive Care, Tartu University Hospital, Tartu, Estonia.
University of Tartu · EETartu University Hospital · EETallinn Health Care College · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to determine factors associated with gut colonization of preterm neonates with coagulase-negative staphylococci (CoNS) from maternal milk (MM). STUDY

designCoNS isolated from weekly collected stool and MM of hospitalized preterm (n = 49) and healthy term neonates (n = 20) were genotyped. Colonization-related factors were determined by Cox proportional hazards regression.

resultGut colonization with mecA-negative Staphylococcus epidermidis from MM was less prevalent (40.8% vs. 95%) and delayed (median age 15.5 vs. 2 days) in preterm compared with term neonates. Enhanced colonization was associated with higher intake of CoNS from MM (hazard ratio (95% confidence interval) 1.006 (1.00-1.01) for 10

conclusionEnteral feeding with larger proportion of unpasteurized MM and limiting spread of predominant strains may promote colonization with CoNS from MM.

Indexed as

Infant, PrematureAdultBreast FeedingCoagulaseFecesFemaleGastrointestinal TractHumansInfant, NewbornIntensive Care Units, NeonatalLongitudinal StudiesMilk, HumanMultilocus Sequence TypingNeonatal SepsisProportional Hazards ModelsProspective StudiesCoagulase

Identifiers

PMID30076401
OpenAlexW2887054135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.