Evidence map›Paper›PMID 30076382›Full record

ArticleScientific reports2018

Phenylephrine, a common cold remedy active ingredient, suppresses uterine contractions through cAMP signalling.

Xingjuan Chen, Marya Meroueh, Gabriela Mazur, Evan Rouse, Karmjot Singh Hundal, Christopher W Stamatkin, Alexander G Obukhov

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Crosstalk of noradrenergic CaCell communication and signaling : CCS · 2026
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  11. Relaxant Effects of the Aqueous Extract ofBioMed research international · 2021
    Article
  12. Analysis ofInterface focus · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Xingjuan ChenDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine - Indianapolis, Indianapolis, Indiana, 46202, USA.
Marya MerouehDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine - Indianapolis, Indianapolis, Indiana, 46202, USA.
Gabriela MazurDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine - Indianapolis, Indianapolis, Indiana, 46202, USA.
Evan RouseDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine - Indianapolis, Indianapolis, Indiana, 46202, USA.
Karmjot Singh HundalDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine - Indianapolis, Indianapolis, Indiana, 46202, USA.
Christopher W StamatkinDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine - Indianapolis, Indianapolis, Indiana, 46202, USA.
Alexander G ObukhovDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine - Indianapolis, Indianapolis, Indiana, 46202, USA. aobukhov@iu.edu.ORCID 0000-0002-3862-6004
Indiana University School of MedicineGreenfield Research (Canada) · CATechSolve (United States) · US

Funding

TRPC Channels in the Metabolic SyndromeR01HL115140 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI OBUKHOV, ALEXANDER G. · 2012 to 2016
$2.6M
NHLBI NIH HHS R01 HL115140
6 · The paper itself

Abstract

Regulation of uterine contractility is an important aspect of women's health. Phenylephrine, a selective agonist of the α

Indexed as

Signal TransductionAnimalsCaffeineCommon ColdCyclic AMPEstradiolFemaleGenitalia, FemaleHumansIntracellular SpaceMice, Inbred C57BLMuscle RelaxationMyocytes, Smooth MuscleOxytocinPeristalsisPhenylephrineCaffeineCyclic AMPEstradiolOxytocinPhenylephrineProgesteroneReceptors, Adrenergic, beta-2

Identifiers

PMID30076382
PMCPMC6076280
OpenAlexW2887962386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.