ArticleMolecular cancer research : MCR2018
CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD
Open access · bronzeAbstract read
In one paragraph
Article in Molecular cancer research : MCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 55 citations in OpenAlex.
- Exercise suppresses breast cancer and reprograms the immune tumor microenvironment, cancer cell intrinsic features, and their interaction.Journal of sport and health science · 2026Article
- Identification and functional analysis of NADFrontiers in genetics · 2026Article
- Propagation of monocyte exhaustion memory and underlying mechanisms.Cell communication and signaling : CCS · 2025Article
- The Oncometabolite 2-Hydroxyglutarate Is Upregulated in Post-Prostatectomy PSA Recurrence of Prostate Cancer: A Metabolomic Analysis.Molecules (Basel, Switzerland) · 2025Article
- CD38 contributes to tumor progression and tumor microenvironment reshaping in epithelial ovarian cancer.Translational oncology · 2025Article
- Exploring the causal relationship between immune factors and chondrosarcoma: a Mendelian randomization study.Discover oncology · 2025Article
- Development of a machine learning-based predictive risk model combining fatty acid metabolism and ferroptosis for immunotherapy response and prognosis in prostate cancer.Discover oncology · 2025Article
- NAD+ metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma.Blood advances · 2025Article
- Unsupervised self-organising map classification of Raman spectra from prostate cell lines uncovers substratified prostate cancer disease states.Scientific reports · 2025Article
- A comprehensive analysis reveals the relationship between artificial sweeteners and prostate cancer.Frontiers in nutrition · 2025Article
- CD38-targeted attenuated interferon alpha immunocytokine activates both innate and adaptive immune cells to drive anti-tumor activity.PloS one · 2025Article
- The dark side of SIRT7.Molecular and cellular biochemistry · 2024Review
- A Novel Prognostic Model of Hepatocellular Carcinoma per Two NAD+ Metabolic Synthesis-Associated Genes.International journal of molecular sciences · 2024Article
- Programmed Cell Death-Related Gene Signature Associated with Prognosis and Immune Infiltration and the Roles of HMOX1 in the Proliferation and Apoptosis were Investigated in Uveal Melanoma.Genes & genomics · 2024Article
- Lactate drives CD38 signaling to promote Epithelial-Mesenchymal Transition through Snail induction in non-small cell lung cancer cells.Journal of cell communication and signaling · 2024Article
- Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas.Purinergic signalling · 2024Article
- Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses.Cell reports · 2023Article
- The interplay between the DNA damage response and ectonucleotidases modulates tumor response to therapy.Science immunology · 2023Review
- CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NADAntioxidants (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Jeffrey P ChmielewskiDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Sarah C BowlbyDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Frances B WheelerDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Lihong ShiDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Guangchao SuiDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Amanda L DavisDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Timothy D HowardDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Ralph B D'AgostinoComprehensive Cancer Center at Wake Forest Baptist Medical Center, Winston-Salem, North Carolina.
Lance D MillerDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0003-3799-2528
S Joseph SirintrapunDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-2921-8831
Scott D CramerDepartment of Pharmacology, University of Colorado Denver, Aurora, Colorado.
Steven J KridelDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina. skridel@wakehealth.edu.
Wake Forest University · USAtrium Health Wake Forest Baptist · USMemorial Sloan Kettering Cancer Center · USUniversity of Colorado Denver · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4MTraining Program in Cancer BiologyT32CA079448 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRIDEL, STEVEN J. · 2000 to 2014
$6.5MCHD1 and MAP3K7 coordinate deletion in aggressive ERG translocation negative prostate cancerR01CA199741 · NCI · UNIVERSITY OF COLORADO DENVER · PI CRAMER, SCOTT D · 2015 to 2019
$1.8MIntegrative Lipid Metabolism, Inflammation, and Chronic DiseasesT32HL091797 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PARKS, JOHN S · 2008 to 2017
$1.8MNAD+ metabolism in prostate cancerR01CA161503 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRIDEL, STEVEN J. · 2012 to 2016
$1.5MNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA161503NCI NIH HHS R01 CA199741NCI NIH HHS T32 CA079448NHLBI NIH HHS T32 HL091797
Abstract
Tumor cells require increased rates of cell metabolism to generate the macromolecules necessary to sustain proliferation. They rely heavily on NAD
Indexed as
AcrylamidesADP-ribosyl Cyclase 1AMP-Activated Protein Kinase KinasesCell Line, TumorCell ProliferationCellular ReprogrammingCytokinesFatty AcidsGene ExpressionHumansLipidsMaleMembrane GlycoproteinsMitochondriaNADNicotinamide PhosphoribosyltransferaseAcrylamidesADP-ribosyl Cyclase 1AMP-Activated Protein Kinase KinasesCD38 protein, humanCytokinesFatty AcidsLipidsMembrane GlycoproteinsN-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamideNADNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanPiperidinesProtein KinasesTretinoin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.