Evidence map›Paper›PMID 30076173›Full record

Trial reportHaematologica2019

Gemtuzumab ozogamicin for

Juliette Lambert, Cécile Pautas, Christine Terré, Emmanuel Raffoux, Pascal Turlure, Denis Caillot, Ollivier Legrand, Xavier Thomas, Claude Gardin, Karïn Gogat-Marchant and 7 more

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05025098 (Precision Therapy Versus Standard Therapy in Acute Myeloid Leukaemia and Myelodysplastic Syndrome in Elderly), which is not on this map. Cited by 197 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 3 pooled it
21.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05025098 phase2recruitingnot on this mapstarted 2021, after this paper: background citation

Precision Therapy Versus Standard Therapy in Acute Myeloid Leukaemia and Myelodysplastic Syndrome in Elderly

TypeinterventionalSponsorUniversity Hospital, AkershusRan2021 to 2027Enrolled36ConditionsAML, Adult, MDSArmsStandard therapy, Precision therapy
3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 3 syntheses or guidelines pooled it, 340 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pivekimab Sunirine in Blastic Plasmacytoid Dendritic Cell Neoplasm.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
    Trial
  5. Trial
  6. Trial
  7. Trial
  8. Gemtuzumab Ozogamicin inJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020
    Trial
  9. The cellular landscape of druggable RNA-binding proteins.Nature reviews. Drug discovery · 2026
    Review
  10. Two Decades ofCancers · 2026
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 2 countries.

Juliette LambertService d'Hématologie et Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France.
Cécile PautasService d'Hématologie et de Thérapie Cellulaire, Hôpital Henri Mondor, Créteil, France.
Christine TerréLaboratoire de Cytogénétique, Centre Hospitalier de Versailles, France.
Emmanuel RaffouxHôpital Saint-Louis (AP-HP), Université Paris Diderot, France.
Pascal TurlureService d'Hématologie Clinique et Thérapie Cellulaire, Centre Hospitalier Universitaire, Limoges, France.
Denis CaillotHematologie Clinique, Hôpital François Mitterrand, Centre Hospitalier Universitaire, Dijon, France.
Ollivier LegrandHôpital Saint-Antoine (AP-HP), Université Paris Pierre et Marie Curie, France.
Xavier ThomasCentre Hospitalier Lyon Sud, Hospices Civils de Lyon, Université Lyon 1, Pierre Benite, France.
Claude GardinHôpital Avicenne (AP-HP), Université Paris 13, Bobigny, France.
Karïn Gogat-MarchantGlobal Clinical Development Pfizer Inc., Paris, France.
Stephen D RubinGlobal Product Development, Pfizer Inc., Collegeville, PA, USA.
Rebecca J BennerGlobal Product Development, Pfizer Inc., Groton, CT, USA.
Pierre BoussetPfizer Oncology, Pfizer Inc., Paris, France.
Claude PreudhommeUniversité Lille, INSERM, Centre Hospitalier Universitaire Lille, UMR-S 1172 - Jean-Pierre Aubert Center - Centre de Recherche, Lille, France.
Sylvie ChevretDepartement de Biostatistique, Hôpital Saint-Louis (AP-HP), Universite Paris Diderot, INSERM S 717, France.
Herve DombretHopital Saint-Louis (AP-HP), Universite Paris Diderot, France.
Sylvie CastaigneService d'Hématologie et Oncologie, Centre Hospitalier de Versailles, Université de Versailles Saint Quentin, Le Chesnay, France scastaigne@ch-versailles.fr.
Centre Hospitalier de Versailles · FRDélégation Paris 7 · FRPfizer (France) · FRPfizer (United States) · USAssistance Publique – Hôpitaux de Paris · FRCentre de Recherche Jean Pierre Aubert · FRCentre Hospitalier Universitaire de Limoges · FRHôpital Saint-Antoine · FRInserm · FRUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The randomized, phase III ALFA-0701 trial showed that a reduced and fractionated dose of gemtuzumab ozogamicin added to standard front-line chemotherapy significantly improves event-free survival (EFS) in adults with

Indexed as

Leukemia, Myeloid, AcuteAdultAgedAntineoplastic Combined Chemotherapy ProtocolsCytarabineDaunorubicinDisease-Free SurvivalFemaleGemtuzumabHumansMaleMiddle AgedSurvival RateCytarabineDaunorubicinGemtuzumab

Identifiers

PMID30076173
PMCPMC6312010
OpenAlexW2886748809

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.