Evidence map›Paper›PMID 30076172›Full record

ArticleHaematologica2018

Diffuse alveolar hemorrhage is most often fatal and is affected by graft source, conditioning regimen toxicity, and engraftment kinetics.

Fatma Keklik, Ezzideen Barjes Alrawi, Qing Cao, Nelli Bejanyan, Armin Rashidi, Aleksandr Lazaryan, Patrick Arndt, Erhan H Dincer, Veronika Bachanova, Erica D Warlick and 6 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  5. Article
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  11. Noninfectious complications of hematopoietic cell transplantation.Hematology. American Society of Hematology. Education Program · 2021
    Article
  12. Article
  13. Review
  14. Noninfectious pulmonary complications of haematopoietic stem cell transplantation.European respiratory review : an official journal of the European Respiratory Society · 2020
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Fatma KeklikDivision of Hematology-Oncology and Transplantation, Department of Medicine.
Ezzideen Barjes AlrawiDivision of Hematology-Oncology and Transplantation, Department of Medicine.
Qing CaoBiostatistics and Bioinformatics.
Nelli BejanyanDivision of Hematology-Oncology and Transplantation, Department of Medicine.
Armin RashidiDivision of Hematology-Oncology and Transplantation, Department of Medicine.
Aleksandr LazaryanDivision of Hematology-Oncology and Transplantation, Department of Medicine.
Patrick ArndtDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine.
Erhan H DincerDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine.
Veronika BachanovaDivision of Hematology-Oncology and Transplantation, Department of Medicine.
Erica D WarlickDivision of Hematology-Oncology and Transplantation, Department of Medicine.
Margaret L MacMillanDivision of Pediatric Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Mukta AroraDivision of Hematology-Oncology and Transplantation, Department of Medicine.
Jeffrey MillerDivision of Hematology-Oncology and Transplantation, Department of Medicine.
Claudio G BrunsteinDivision of Hematology-Oncology and Transplantation, Department of Medicine.
Daniel J WeisdorfDivision of Hematology-Oncology and Transplantation, Department of Medicine.
Celalettin UstunDivision of Hematology-Oncology and Transplantation, Department of Medicine celalettin_ustun@rush.edu.
University of Minnesota · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
Trial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI J SUNIL RAO · 1995 to 2026
$48.2M
NCI NIH HHS P01 CA065493NCI NIH HHS P30 CA077598
6 · The paper itself

Abstract

Diffuse alveolar hemorrhage after hematopoietic stem cell transplantation is a frequently fatal complication with no standard therapy. Although significant changes in supportive and intensive care measures for patients undergoing hematopoietic stem cell transplantation have been made over the past decades, the impact of these changes on the incidence and outcome of patients with diffuse alveolar hemorrhage has not been examined. We analyzed 1228 patients who underwent allogeneic hematopoietic stem cell transplantation between 2008-2015 at the University of Minnesota to study the incidence, risk factors, and outcomes of diffuse alveolar hemorrhage. Diffuse alveolar hemorrhage developed in 5% of allogeneic hematopoietic stem cell transplant recipients, at a median of 30 days (range +3 to +168 days) after transplantation. The incidence of diffuse alveolar hemorrhage was significantly greater in recipients of umbilical cord blood than peripheral blood or bone marrow grafts (HR: 2.08, 95% CI: 1.16-3.74;

Indexed as

AdolescentAdultAgedBone Marrow TransplantationChildChild, PreschoolCord Blood Stem Cell TransplantationFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHemorrhageHumansInfantInfant, NewbornKineticsMale

Identifiers

PMID30076172
PMCPMC6269296
OpenAlexW2885865830

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.