ArticleBlood2018
Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development.
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Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- ZMIZ1 promotes aerobic glycolysis and development of hepatocellular carcinoma through inducing NOTCH1-mediated transcription of PYCR1.Journal of translational medicine · 2026Article
- Epigenetic programming by H3K23ac defines lineage fate of Meg3Nature cell biology · 2026Article
- Targeting ZMIZ1 induces differentiation in acute myeloid leukemia via chromatin remodeling.Signal transduction and targeted therapy · 2026Article
- Nephron-associated Support Cell Transcriptional Plasticity Expands in Hypertension.bioRxiv : the preprint server for biology · 2026Article
- A Functional Genetic Score in the ZMIZ1/TGF-β/STAT Pathway Predicts Early Biologic Discontinuation in Psoriasis Patients Treated with Anti-TNF and Anti-IL12/23 Agents.Advances in therapy · 2025Article
- ZMIZ1 and estrogen receptor α form an essential partnership in endometrial biology.The Journal of clinical investigation · 2025Article
- Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks.Nature genetics · 2025Article
- Native stem cell transcriptional circuits define cardinal features of high-risk leukemia.The Journal of experimental medicine · 2025Article
- Association of genetic variants, protein domains, and phenotypes in the ZMIZ1 syndromic neurodevelopmental disorder.Frontiers in neuroscience · 2025Article
- Immune Microenvironment Characterization and Machine Learning-Guided Identification of Diagnostic Biomarkers for Ulcerative Colitis.Journal of inflammation research · 2025Article
- Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer.Cellular & molecular biology letters · 2024Article
- ZMIZ1 enhances ERα-dependent expression of E2F2 in breast cancer.Journal of molecular endocrinology · 2024Article
- Targeting the ZMIZ1-Notch1 signaling axis for the treatment of tongue squamous cell carcinoma.Scientific reports · 2024Article
- Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function.PloS one · 2024Article
- Zmiz1 is a novel regulator of brain development associated with autism and intellectual disability.Frontiers in psychiatry · 2024Article
- Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk.British journal of cancer · 2023Article
- Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function.bioRxiv : the preprint server for biology · 2023Article
- ZMIZ proteins: partners in transcriptional regulation and risk factors for human disease.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Transcriptional Regulation of Early T-Lymphocyte Development in Thymus.Frontiers in immunology · 2022Review
- Logic and lineage impacts on functional transcription factor deployment for T-cell fate commitment.Biophysical journal · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 1 country.
Qing WangDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.
Ran YanDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.
Nancy PinnellDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.
Anna C McCarterCell and Molecular Biology Program, Medical School, University of Michigan, Ann Arbor, MI.
Yeonjoo OhDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.
Yiran LiuDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.
Cher ShaDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.
Noah F GarberDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.
Yitong ChenDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.
Qingqing WuCincinnati Children's Hospital Medical Center, Cincinnati, OH.
Chia-Jui KuDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI.
Ivy TranLife Sciences Institute and.
Amparo Serna AlarconDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.
Rork KuickDepartment of Biostatistics, Medical School, University of Michigan, Ann Arbor, MI.
James Douglas EngelDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI.
Ivan MaillardDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.
Tomasz CierpickiDepartment of Pathology, Medical School, University of Michigan, Ann Arbor, MI.
Mark Y ChiangDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-2099-0956
University of Michigan · USCancer Research Institute · USCincinnati Children's Hospital Medical Center · USCold Spring Harbor Laboratory · US
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2MCELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8MTraining Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3MNotch Signaling in AlloimmunityR01AI091627 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI PEAR, WARREN S · 2011 to 2025
$6.0MDirect coregulation of Notch1 by Zmiz1 in T-cell leukemiaR01CA196604 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHIANG, MARK Y · 2015 to 2019
$1.8MExploiting the Context-Dependence of Notch to Develop Safer T-ALL therapyF30CA228228 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCARTER, ANNA CATHERINE · 2018 to 2020
$78kNCI NIH HHS F30 CA228228NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA196604NCI NIH HHS T32 CA009676NIAID NIH HHS R01 AI091627NIGMS NIH HHS T32 GM007315
Abstract
Notch1 signaling must elevate to high levels in order to drive the proliferation of CD4
Indexed as
AnimalsCell ProliferationGene DeletionGene Expression Regulation, LeukemicHumansIntracellular Signaling Peptides and ProteinsLeukemia, T-CellMiceModels, MolecularProtein Interaction MapsProto-Oncogene Proteins c-mycReceptor, Notch1RNA-Binding ProteinsThymus GlandT-LymphocytesIntracellular Signaling Peptides and ProteinsNotch1 protein, mouseProto-Oncogene Proteins c-mycReceptor, Notch1RNA-Binding ProteinsZimp10 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.