ArticleBiomaterials2019
Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings.
Article in Biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Single-cell transcriptomics-guided dynamic hydrogel delivery of artemisia argyi-derived EVs relieves ER stress and promotes diabetic wound regeneration.Journal of nanobiotechnology · 2026Article
- Delivery timing determines senomorphic efficacy: delayed local ruxolitinib restores macrophage polarization and rescues age-impaired bone repair.Research square · 2026Article
- Sequential polarization of macrophages: an immunomodulatory strategy for novel bone repair materials.Regenerative biomaterials · 2026Review
- Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives.Bioactive materials · 2025Review
- Affinity-based controlled release of interleukin-4 from scaffolds via biotin-streptavidin interactions for immunomodulation.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- Unraveling osteogenesis mechanisms of the empowered VitaFlux adaptive regeneration biomaterials for bone tissue engineering: Insights into the role of BBGs/BSBGs.Bioactive materials · 2025Review
- Cell-Type-Specific ROS-AKT/mTOR-Autophagy Interplay-Should It Be Addressed in Periimplantitis?Diagnostics (Basel, Switzerland) · 2024Review
- TiAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Unraveling and Harnessing the Immune Response at the Cell-Biomaterial Interface for Tissue Engineering Purposes.Advanced healthcare materials · 2024Review
- Effects of bone surface topography and chemistry on macrophage polarization.Scientific reports · 2024Article
- Understanding the properties of intermittent catheters to inform future development.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2024Review
- Integrating osteoimmunology and nanoparticle-based drug delivery systems for enhanced fracture healing.Nanomedicine : nanotechnology, biology, and medicine · 2024Review
- Biomimetic Therapeutics for Bone Regeneration: A Perspective on Antiaging Strategies.Macromolecular bioscience · 2024Review
- Modelling of macrophage responses to biomaterialsFrontiers in immunology · 2024Review
- CXCL chemokines-mediated communication between macrophages and BMSCs on titanium surface promotes osteogenesis via the actin cytoskeleton pathway.Materials today. Bio · 2023Article
- A new osteogenic protein isolated fromBioactive materials · 2023Article
- Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation.Bioactive materials · 2023Review
- Preparation of co-electrospinning membrane loaded with simvastatin and substance P to accelerate bone regeneration by promoting cell homing, angiogenesis and osteogenesis.Materials today. Bio · 2023Article
- Sex differences in depression: An immunological perspective.Brain research bulletin · 2023Review
- Polarization Behavior of Bone Macrophage as Well as Associated Osteoimmunity in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.Journal of inflammation research · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Older adults suffer from weakened and delayed bone healing due to age-related alterations in bone cells and in the immune system. Given the interaction between the immune system and skeletal cells, therapies that address deficiencies in both the skeletal and the immune system are required to effectively treat bone injuries of older patients. The sequence of macrophage activation observed in healthy tissue repair involves a transition from a pro-inflammatory state followed by a pro-reparative state. In older patients, inflammation is slower to resolve and impedes healing. The goal of this study was to design a novel drug delivery system for temporal guidance of the polarization of macrophages using bone grafting materials. A biomimetic calcium phosphate coating (bCaP) physically and temporally separated the pro-inflammatory stimulus interferon-gamma (IFNγ) from the pro-reparative stimulus simvastatin (SIMV). Effective doses were identified using a human monocyte line (THP-1) and testing culminated with bone marrow macrophages obtained from old mice. Sequential M1-to-M2 activation was achieved with both cell types. These results suggest that this novel immunomodulatory drug delivery system holds potential for controlling macrophage activation in bones of older patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.