Evidence map›Paper›PMID 30075815›Full record

ArticleClinical epigenetics2018

Increased CD4

Emma Ahlén Bergman, Ciputra Adijaya Hartana, Markus Johansson, Ludvig B Linton, Sofia Berglund, Martin Hyllienmark, Christian Lundgren, Benny Holmström, Karin Palmqvist, Johan Hansson and 11 more

Abstract read
In one paragraph

Article in Clinical epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Identification and validation of a CD4BMC gastroenterology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
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  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Targeting the Immune system and Epigenetic Landscape of Urological Tumors.International journal of molecular sciences · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Emma Ahlén BergmanUnit of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. emma.ahlen.bergman@ki.se.ORCID 0000-0002-6957-7129
Ciputra Adijaya HartanaUnit of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Markus JohanssonDepartment of Urology, Sundsvall Hospital, Sundsvall, Sweden.
Ludvig B LintonUnit of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Sofia BerglundUnit of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Martin HyllienmarkTLA Targeted Immunotherapies AB, Stockholm, Sweden.
Christian LundgrenUnit of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Benny HolmströmDepartment of Urology, Akademiska University Hospital, Uppsala, Sweden.
Karin PalmqvistDepartment of surgical and perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Johan HanssonCentre for Research and Development, Faculty of Medicine, Uppsala University, County Council of Gävleborg, Uppsala, Sweden.
Farhood AlamdariDepartment of Urology, Västmanland Hospital, Västerås, Sweden.
Ylva HugeDepartment of Clinical and Experimental Medicine, Division of Urology, Linköping University, Linköping, Sweden.
Firas AljaberyDepartment of Clinical and Experimental Medicine, Division of Urology, Linköping University, Linköping, Sweden.
Katrine RiklundDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden.
Malin E WinerdalUnit of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
David KrantzUnit of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
A Ali ZirakzadehUnit of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Per MaritsUnit of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Louise K SjöholmCenter for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Amir SherifDepartment of surgical and perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Ola WinqvistUnit of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUrinary bladder cancer is a common malignancy worldwide. Environmental factors and chronic inflammation are correlated with the disease risk. Diagnosis is performed by transurethral resection of the bladder, and patients with muscle invasive disease preferably proceed to radical cystectomy, with or without neoadjuvant chemotherapy. The anti-tumour immune responses, known to be initiated in the tumour and draining lymph nodes, may play a major role in future treatment strategies. Thus, increasing the knowledge of tumour-associated immunological processes is important. Activated CD4

resultsBlood, tumour and regional lymph nodes were obtained from patients at time of transurethral resection of the bladder and at radical cystectomy. Tumour-infiltrating CD4

conclusionIncreased lineage commitment in CD4

Indexed as

DNA MethylationAgedAged, 80 and overCD4-Positive T-LymphocytesCell DifferentiationCell LineageCells, CulturedCpG IslandsCystectomyDrug TherapyEpigenesis, GeneticFemaleForkhead Transcription FactorsHumansInterferon-gammaInterleukin-13Forkhead Transcription FactorsFOXP3 protein, humanIFNG protein, humanIL13 protein, humanIL17A protein, humanInterferon-gammaInterleukin-13Interleukin-17CD4-positive T lymphocytesDNA methylationUrinary bladder neoplasms

Identifiers

PMID30075815
PMCPMC6076404

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.