ArticleBreast cancer research : BCR2018
The added value of mammography in different age-groups of women with and without BRCA mutation screened with breast MRI.
Article in Breast cancer research : BCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Cost-Effectiveness Analysis of Imaging Modalities for Breast Cancer Surveillance AmongFrontiers in oncology · 2021Pooled it
- Hereditary diffuse gastric cancer: updated clinical practice guidelines.The Lancet. Oncology · 2020Guideline
- Diagnostic sensitivity of mammography and magnetic resonance imaging for ductal carcinomaChinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Breast cancer in women after withdrawing from an increased-risk MRI screening program.European radiology · 2025Article
- Defining Lifetime Risk Thresholds for Breast Cancer Surgical Prevention.JAMA oncology · 2025Article
- Advances in Risk Management and Screening for Women at Increased Risk of Breast Cancer: The Role of MR Imaging and Personalised Approaches.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Review
- Breast Cancer: Impact of New Treatments?Cancers · 2023Article
- Prevalent versus incident breast cancers: benefits of clinical and radiological monitoring in women with pathogenic BRCA1/2 variants.European journal of human genetics : EJHG · 2022Article
- The yield and effectiveness of breast cancer surveillance in women with PTEN Hamartoma Tumor Syndrome.Cancer · 2022Article
- Hereditary Diffuse Gastric Cancer: Molecular Genetics, Biological Mechanisms and Current Therapeutic Approaches.International journal of molecular sciences · 2022Review
- MRI versus Mammography plus Ultrasound in Women at Intermediate Breast Cancer Risk: Study Design and Protocol of the MRIB Multicenter, Randomized, Controlled Trial.Diagnostics (Basel, Switzerland) · 2021Article
- Screening Algorithms in Dense Breasts:AJR. American journal of roentgenology · 2021Review
- Magnetic Resonance Imaging in Screening of Breast Cancer.Radiologic clinics of North America · 2021Review
- The Distinct Performances of Ultrasound, Mammograms, and MRI in Detecting Breast Cancer in Patients With Germline Pathogenic Variants in Cancer Predisposition Genes.Frontiers in oncology · 2021Article
- Evaluation of breast screening strategies in a high risk breast and ovarian cancer clinic.Gynecologic oncology reports · 2020Article
- The supplemental value of mammographic screening over breast MRI alone in BRCA2 mutation carriers.Breast cancer research and treatment · 2020Article
- The clinical impact of MRI screening for BRCA mutation carriers: the first report in Japan.Breast cancer (Tokyo, Japan) · 2019Article
- Contrast-enhanced MRI for breast cancer screening.Journal of magnetic resonance imaging : JMRI · 2019Review
- Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast magnetic resonance imaging (MRI) is the most sensitive imaging method for breast cancer detection and is therefore offered as a screening technique to women at increased risk of developing breast cancer. However, mammography is currently added from the age of 30 without proven benefits. The purpose of this study is to investigate the added cancer detection of mammography when breast MRI is available, focusing on the value in women with and without BRCA mutation, and in the age groups above and below 50 years.
methodsThis retrospective single-center study evaluated 6553 screening rounds in 2026 women at increased risk of breast cancer (1 January 2003 to 1 January 2014). Risk category (BRCA mutation versus others at increased risk of breast cancer), age at examination, recall, biopsy, and histopathological diagnosis were recorded. Cancer yield, false positive recall rate (FPR), and false positive biopsy rate (FPB) were calculated using generalized estimating equations for separate age categories (< 40, 40-50, 50-60, ≥ 60 years). Numbers of screens needed to detect an additional breast cancer with mammography (NSN) were calculated for the subgroups.
resultsOf a total of 125 screen-detected breast cancers, 112 were detected by MRI and 66 by mammography: 13 cancers were solely detected by mammography, including 8 cases of ductal carcinoma in situ. In BRCA mutation carriers, 3 of 61 cancers were detected only on mammography, while in other women 10 of 64 cases were detected with mammography alone. While 77% of mammography-detected-only cancers were detected in women ≥ 50 years of age, mammography also added more to the FPR in these women. Below 50 years the number of mammographic examinations needed to find an MRI-occult cancer was 1427.
conclusionsMammography is of limited added value in terms of cancer detection when breast MRI is available for women of all ages who are at increased risk. While the benefit appears slightly larger in women over 50 years of age without BRCA mutation, there is also a substantial increase in false positive findings in these women.
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