Evidence map›Paper›PMID 30075755›Full record

ArticleBMC neuroscience2018

Differential modulation of human GABA

Lenin David Ochoa-de la Paz, Martin González-Andrade, Herminia Pasantes-Morales, Rodrigo Franco, Rubén Zamora-Alvarado, Edgar Zenteno, Hugo Quiroz-Mercado, Roberto Gonzales-Salinas, Rosario Gulias-Cañizo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. GABAFrontiers in pharmacology · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lenin David Ochoa-de la PazDepartamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Copilco Universidad, Cd. Universitaria, 04510, México City, México. lochoa@unam.mx.ORCID 0000-0002-7561-0853
Martin González-AndradeDepartamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Copilco Universidad, Cd. Universitaria, 04510, México City, México.
Herminia Pasantes-MoralesDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Coyoacán, Ciudad Universitaria, 04510, Mexico City, Mexico.
Rodrigo FrancoRedox Biology Center and School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
Rubén Zamora-AlvaradoDepartamento de Investigación APEC, Asociación para Evitar la Ceguera en México I.A.P. Hospital Dr. Luis Sánchez Bulnes, Fernández Leal 60, Col. La Concepción Coyoacán, 04020, Mexico City, Mexico.
Edgar ZentenoDepartamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Copilco Universidad, Cd. Universitaria, 04510, México City, México.
Hugo Quiroz-MercadoDepartamento de Investigación APEC, Asociación para Evitar la Ceguera en México I.A.P. Hospital Dr. Luis Sánchez Bulnes, Fernández Leal 60, Col. La Concepción Coyoacán, 04020, Mexico City, Mexico.
Roberto Gonzales-SalinasDepartamento de Investigación APEC, Asociación para Evitar la Ceguera en México I.A.P. Hospital Dr. Luis Sánchez Bulnes, Fernández Leal 60, Col. La Concepción Coyoacán, 04020, Mexico City, Mexico.
Rosario Gulias-CañizoDepartamento de Investigación APEC, Asociación para Evitar la Ceguera en México I.A.P. Hospital Dr. Luis Sánchez Bulnes, Fernández Leal 60, Col. La Concepción Coyoacán, 04020, Mexico City, Mexico.
Asociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes · MXUniversidad Nacional Autónoma de México · MXUniversity of Nebraska–Lincoln · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe amino acid taurine (2-Aminoethanesulfonic acid) modulates inhibitory neurotransmitter receptors. This study aimed to determine if the dual action of taurine on GABA

resultsIn Xenopus laevis oocytes, hypotaurine and homotaurine partially activate heterologously expressed GABA

conclusionsThe sulfur-containing compounds structurally related to taurine are partial agonists of GABA

Indexed as

Animalsgamma-Aminobutyric AcidPatch-Clamp TechniquesReceptors, GABASulfur CompoundsTaurineXenopus laevisgamma-Aminobutyric AcidhypotaurineReceptors, GABASulfur CompoundsTaurineGABA receptorHomotaurineHypotaurineIsethionic acidReceptor modulationSulfur-containing compoundsTaurineXenopus oocytes

Identifiers

PMID30075755
PMCPMC6076408
OpenAlexW2886078744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.