SynthesisMedicine2018
Diagnostic value of serum ICAM-1 for endometriosis: A meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Hypoxia-induced regulations of cell adhesion molecules and their implications for pathogenesis, diagnosis, and treatment of endometriosis.Frontiers in molecular biosciences · 2026Review
- Review
- Increased serum LOXL2 concentration in pelvic inflammatory disease with pelvic adhesion.BMC women's health · 2022Article
- Epigenetic regulation and T-cell responses in endometriosis - something other than autoimmunity.Frontiers in immunology · 2022Review
- Current and Future Roles of Circular RNAs in Normal and Pathological Endometrium.Frontiers in endocrinology · 2021Review
- Single-Cell Immune Profiling in Coronary Artery Disease: The Role of State-of-the-Art Immunophenotyping With Mass Cytometry in the Diagnosis of Atherosclerosis.Journal of the American Heart Association · 2020Review
- Comparison of the Analgesic and Anti-Inflammatory Effects of Xiaoyuningkun Decoction with Cynanchum Paniculatum and Fukeqianjin in a Mouse Model of Pelvic Inflammatory Disease.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have evaluated the diagnostic value of serum intercellular adhesion molecule-1 (ICAM-1) in patients with endometriosis, but the results remained inconsistent. This meta-analysis aimed to clarify the overall diagnostic accuracy of serum ICAM-1 for endometriosis.
methodsA systematic search was performed of the Cochrane clinical trials database, PubMed, and Embase prior to December 2017. Sensitivity, specificity, and other measures were pooled and determined to evaluate the accuracy of serum ICAM-1 in the diagnosis of endometriosis. Summary receiver operating characteristic curve (SROC) analysis with calculation of the area under curve (AUC) was performed to summarize the overall test performance.
resultsNine studies including 878 patients were eligible for inclusion in the analysis. The summary estimates of sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio (95% confidence interval) were 0.65 (0.52-0.75), 0.78 (0.62-0.89), 3.0 (1.7-5.2), 0.45 (0.34-0.60), and 7 (3-13), respectively, and the AUC of the overall analysis was 0.76 (0.72-0.80). Subgroup analysis showed that the summary sensitivity and specificity for patients of Asian ethnicity was increased compared with those of Caucasian ethnicity. The summary specificity was increased in studies with a high ICAM-1 cut-off value compared to those with a low cut-off value. No publication bias was found across the studies.
conclusionsOur results suggest that serum ICAM-1 has moderate diagnostic accuracy for endometriosis, while the diagnostic accuracy is higher in patients of Asian ethnicity compared with those of Caucasian ethnicity.
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