Observational studyMedicine2018
Maternal pregnancy-induced hypertension increases subsequent neonatal necrotizing enterocolitis risk: A nationwide population-based retrospective cohort study in Taiwan.
Observational study in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Risk factors for necrotizing enterocolitis in preterm infants: a Meta analysis.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Pooled it
- Association of initial empirical antibiotic therapy with increased risk of necrotizing enterocolitis.European journal of pediatrics · 2020Pooled it
- Distinct clinical patterns of preterm infants vulnerable to intestinal injury identified by unsupervised clustering.Pediatric research · 2026Article
- Evaluation of a Clinical Risk Score for Preterm Necrotising Enterocolitis: The 'Check-NEC Score'.Journal of paediatrics and child health · 2026Article
- Hypoxic-ischemic enterocolitis in extremely low birth weight infants: diagnostic insights from a pilot study.European journal of pediatrics · 2026Article
- Placental abruption and the risk of necrotizing enterocolitis in neonates with birth weight ≥1500 grams; US national database study.Pediatric research · 2025Article
- Pregnancy-Induced Hypertension Pathophysiology and Contemporary Management Strategies: A Narrative Review.Cureus · 2024Review
- Effects of hypertension and use of antihypertensive drugs in pregnancy on the risks of childhood cancers in Taiwan.Cancer causes & control : CCC · 2024Article
- Risk factors of necrotizing enterocolitis among neonates admitted to the neonatal intensive care unit at the selected public hospitals in southern Ethiopia, 2023.Frontiers in pediatrics · 2024Article
- Necrotizing Enterocolitis: The Role of Hypoxia, Gut Microbiome, and Microbial Metabolites.International journal of molecular sciences · 2023Review
- Impact of hypertensive disorders of pregnancy on neonatal outcomes among infants born at 24Frontiers in pediatrics · 2023Article
- Comparison of clinical outcomes between active and permissive blood pressure management in extremely preterm infants.NIHR open research · 2023Article
- Risk factors for necrotizing enterocolitis in neonates: A meta-analysis.Frontiers in pediatrics · 2022Review
- [Clinical features of very preterm small-for-gestational-age infants born due to severe preeclampsia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Association Between Preeclampsia Risk and Fine Air Pollutants and Acidic Gases: A Cohort Analysis in Taiwan.Frontiers in public health · 2021Article
- Hypertension induced by pregnancy and neonatal outcome: Results from a retrospective cohort study in preterm under 34 weeks.PloS one · 2021Article
- Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The utero-placental ischemia induced by pregnancy-induced hypertension (PIH) could lead to fetal hypoxia and proinflammatory cytokine release, which are associated with the development of neonatal necrotizing enterocolitis (NEC). However, a few studies have investigated the relationship between PIH and neonatal NEC and have produced controversial results. Therefore, we attempted to assess the relationship between PIH and the subsequent neonatal NEC risk and identify predictive risk factors.Patients with newly diagnosed PIH were recruited from the Taiwan National Health Insurance Research Database (NHIRD). For each participant, 4 age- and delivery-year-matched participants without PIH were randomly selected. A multivariable logistic regression was performed for the identification of the predictive risk factors for neonatal NEC.Among the 23.3 million individuals registered in the NHIRD, 29,013 patients with PIH and 116,052 matched controls were identified. For the multivariable analysis, maternal PIH was associated with an increased risk of subsequent neonatal NEC development (odds ratio [OR] 1.86, 95% confidence interval [CI] 1.08-3.21, P = .026). Furthermore, single parity (OR 2.06, 95% CI 1.12-3.77, P = .019), preterm birth (OR 5.97, 95% CI 3.49-10.20, P < .001), multiple gestations (OR 2.25, 95% CI 1.22-4.14, P = .010), and intrauterine growth restriction (IUGR) (OR 3.59, 95% CI 2.06-6.24, P < .001) were independent risk factors for the development of subsequent neonatal NEC.Maternal PIH increases the risk for developing neonatal NEC. Furthermore, primiparity, preterm birth, multiple gestations, and IUGR were independent risk factors for neonatal NEC.
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