ArticleJournal of photochemistry and photobiology. B, Biology2018
Comparison of two functionalized fullerenes for antimicrobial photodynamic inactivation: Potentiation by potassium iodide and photochemical mechanisms.
Article in Journal of photochemistry and photobiology. B, Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 44 citations in OpenAlex.
- Clinical feasibility of chairside methylene blue-mediated photodynamic therapy for oral candidiasis.BMC oral health · 2026Trial
- Simultaneous effect of medicinal plants as natural photosensitizers and low-level laser on photodynamic inactivation.Lasers in medical science · 2024Article
- Sulfonamide Porphyrins as Potent Photosensitizers against Multidrug-ResistantMolecules (Basel, Switzerland) · 2023Article
- Antimicrobial Photodynamic Effect of Cross-Kingdom Microorganisms with Toluidine Blue O and Potassium Iodide.International journal of molecular sciences · 2022Article
- Development of a Polymeric Film Entrapping Rose Bengal and Iodide Anion for the Light-Induced Generation and Release of Bactericidal Hydrogen Peroxide.International journal of molecular sciences · 2022Article
- In Vivo Potentiation of Antimicrobial Photodynamic Therapy in a Mouse Model of Fungal Infection by Addition of Potassium Iodide.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Antimicrobial Photodynamic Approach in the Inactivation of Viruses in Wastewater: Influence of Alternative Adjuvants.Antibiotics (Basel, Switzerland) · 2021Article
- The Remarkable Effect of Potassium Iodide in Eosin and Rose Bengal Photodynamic Action againstAntibiotics (Basel, Switzerland) · 2019Article
- Complexation with CNanoscale research letters · 2019Article
- Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases.International journal of nanomedicine · 2019Review
- An Insight Into the Potentiation Effect of Potassium Iodide on aPDT Efficacy.Frontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
A new fullerene (BB4-PPBA) functionalized with a tertiary amine and carboxylic acid was prepared and compared with BB4 (cationic quaternary group) for antimicrobial photodynamic inactivation (aPDI). BB4 was highly active against Gram-positive methicillin resistant Staphylococcus aureus (MRSA) and BB4-PPBA was moderately active when activated by blue light. Neither compound showed much activity against Gram-negative Escherichia coli or fungus Candida albicans. Therefore, we examined potentiation by addition of potassium iodide. Both compounds were highly potentiated by KI (1-6 extra logs of killing). BB4-PPBA was potentiated more than BB4 against MRSA and E. coli, while for C. albicans the reverse was the case. Addition of azide potentiated aPDI mediated by BB4 against MRSA, but abolished the potentiation caused by KI with both compounds. The killing ability after light decayed after 24 h in the case of BB4, implying a contribution from hypoiodite as well as free iodine. Tyrosine was readily iodinated with BB4-PPBA plus KI, but less so with BB4. We conclude that the photochemical mechanisms of these two fullerenes are different. BB4-PPBA is more Type 2 (singlet oxygen) while BB4 is more Type 1 (electron transfer). There is also a possibility of direct bacterial killing by electron transfer, but this will require more study to prove.
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Registered trials
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