Evidence map›Paper›PMID 30075313›Full record

SynthesisClinical psychology review2018

Risk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis.

J E J Buckman, A Underwood, K Clarke, R Saunders, S D Hollon, P Fearon, S Pilling

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical psychology review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05963581 (Investigating the Effects of Social Movement on Mood and Social and Emotional Functioning in Young People Experiencing Low Mood), which is not on this map. Cited by 173 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 20 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05963581 nacompletednot on this mapstarted 2023, after this paper: background citation

Investigating the Effects of Social Movement on Mood and Social and Emotional Functioning in Young People Experiencing Low Mood

TypeinterventionalSponsorUniversity of OxfordRan2023 to 2024Enrolled121ConditionsDepression, Low Mood, Depressive Disorder, Mood DisordersArmsSalsa Dancing
3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 20 syntheses or guidelines pooled it.

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  3. Early-stage profiles of adolescent mental health difficulties and well-being: A systematic review of cluster analyses in large school and community samples.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025
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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J E J BuckmanResearch Department of Clinical, Educational and Health Psychology, University College London, London, UK. Electronic address: joshua.buckman@ucl.ac.uk.
A UnderwoodResearch Department of Clinical, Educational and Health Psychology, University College London, London, UK.
K ClarkeResearch Department of Clinical, Educational and Health Psychology, University College London, London, UK.
R SaundersResearch Department of Clinical, Educational and Health Psychology, University College London, London, UK.
S D HollonDepartment of Psychology, Vanderbilt University, Nashville, TN, USA.
P FearonResearch Department of Clinical, Educational and Health Psychology, University College London, London, UK.
S PillingResearch Department of Clinical, Educational and Health Psychology, University College London, London, UK.

Funding

Wellcome Trust 201292/Z/16/ZWellcome Trust 20,129/Z/16/Z
6 · The paper itself

Abstract

purposeTo review and synthesise prognostic indices that predict subsequent risk, prescriptive indices that moderate treatment response, and mechanisms that underlie each with respect to relapse and recurrence of depression in adults. RESULTS AND

conclusionsChildhood maltreatment, post-treatment residual symptoms, and a history of recurrence emerged as strong prognostic indicators of risk and each could be used prescriptively to indicate who benefits most from continued or prophylactic treatment. Targeting prognostic indices or their "down-stream" consequences will be particularly beneficial because each is either a cause or a consequence of the causal mechanisms underlying risk of recurrence. The cognitive and neural mechanisms that underlie the prognostic indices are likely addressed by the effects of treatments that are moderated by the prescriptive factors. For example, psychosocial interventions that target the consequences of childhood maltreatment, extending pharmacotherapy or adapting psychological therapies to deal with residual symptoms, or using cognitive or mindfulness-based therapies for those with prior histories of recurrence. Future research that focuses on understanding causal pathways that link childhood maltreatment, or cognitive diatheses, to dysfunction in the neocortical and limbic pathways that process affective information and facilitate cognitive control, might result in more enduring effects of treatments for depression.

Indexed as

DepressionHumansMajor Depressive DisorderPrognosisRecurrenceRisk FactorsSecondary PreventionDepressionDepressive disorderMajorRecurrenceReviewRisk factors

Identifiers

PMID30075313
PMCPMC6237833

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.