ArticleHeart rhythm2019
Minimally invasive transtracheal cardiac plexus block for sympathetic neuromodulation.
Article in Heart rhythm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Anatomy, Imaging, and Clinical Significance of the Cervicothoracic (Stellate) Ganglion.Diagnostics (Basel, Switzerland) · 2025Review
- Hypoxaemic load in sleep apnoea is associated with acute changes in T-wave amplitude.ERJ open research · 2024Article
- Recent advances in convex probe endobronchial ultrasound: a narrative review.Annals of translational medicine · 2021Review
- Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse.Scientific reports · 2021Article
- Therapeutic Potential of Ultrasound Neuromodulation in Decreasing Neuropathic Pain: Clinical and Experimental Evidence.Current neuropharmacology · 2021Review
- Endobronchial ultrasound-guided transtracheal cardiac plexus neuromodulation for refractory ventricular tachycardia.HeartRhythm case reports · 2020Article
- Neuromodulation for the Treatment of Heart Rhythm Disorders.JACC. Basic to translational science · 2019Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBilateral thoracoscopic stellectomy has antiarrhythmic effects, but the procedure is invasive with associated morbidity. Sympathetic nerves from both stellate ganglia form the deep cardiac plexus (CP) in the aortopulmonary window, anterior to the trachea.
objectiveThe purpose of this study was to demonstrate a novel and minimally invasive transtracheal approach to block the CP in porcine models.
methodsIn 12 Yorkshire pigs, right (RSG) and left (LSG) stellate ganglia were electrically stimulated and sympathetic baseline response recorded (hemodynamic parameters and T-wave pattern). Aortopulmonary window was accessed transtracheally with endobronchial ultrasound guidance, and local stimulation of CP confirmed the location. Injection of 1% lidocaine (n = 10) or saline solution (n = 2) was performed, and RSG and LSG responses were re-evaluated and compared with baseline.
resultsTranstracheal lidocaine injection into the CP successfully blocked bilateral sympathetic induced changes (%) in T-wave amplitude (282.8% ± 152.2% vs 20.1% ± 16.5%; P <.001 [LSG]; 338.9% ± 189.8% vs 28% ± 18.3%; P <.001 [RSG]), Tp-Te interval (87.9% ± 37.2% vs 6.9% ± 6.7%; P <.001 [LSG]; 32.6% ± 27.4% vs 6.9% ± 4.7%; P <.035 [RSG]), and left ventricular dP/dT
conclusionMinimally invasive transtracheal injection of lidocaine into the CP blocked the sympathetic response of either RSG and LSG. Transtracheal assessment of CP may allow for minimally invasive and selective ablation of cardiac innervation, extending the cardiac sympathectomy denervation benefits to those not suitable for surgery.
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Registered trials
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