ArticleNeuroscience2018
Social Dominance Modulates Stress-induced Neural Activity in Medial Prefrontal Cortex Projections to the Basolateral Amygdala.
Article in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- The Theoretical Evolution of Social Memory and the Core Contribution of the Medial Prefrontal Cortex.Neuroscience bulletin · 2026Review
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Sleep patterns predicting stress resilience are dependent on sex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Distinguishing neural ensembles in the infralimbic cortex that regulate stress vulnerability and coping behavior.Neurobiology of stress · 2025Article
- Activation of androgen receptor-expressing neurons in the posterior medial amygdala is associated with stress resistance in dominant male hamsters.Hormones and behavior · 2024Article
- Distinct transcriptional programs define a heterogeneous neuronal ensemble for social interaction.iScience · 2024Article
- Acetylcholine muscarinic M1 receptors in the rodent prefrontal cortex modulate cognitive abilities to establish social hierarchy.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Distinct transcriptional programs define a heterogeneous neuronal ensemble for social interaction.bioRxiv : the preprint server for biology · 2023Article
- Dominance status modulates activity in medial amygdala cells with projections to the bed nucleus of the stria terminalis.Behavioural brain research · 2023Article
- The interaction between social hierarchy and depression/anxiety: Involvement of glutamatergic pyramidal neurons in the medial prefrontal cortex (mPFC).Neurobiology of stress · 2023Article
- Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats.Neuroscience and biobehavioral reviews · 2023Review
- Using social rank as the lens to focus on the neural circuitry driving stress coping styles.Current opinion in neurobiology · 2021Review
- Delineating the organization of projection neuron subsets in primary visual cortex with multiple fluorescent rabies virus tracing.Brain structure & function · 2021Article
- Molecular and neurocircuitry mechanisms of social avoidance.Cellular and molecular life sciences : CMLS · 2021Review
- Neural Circuits for Social Interactions: From Microcircuits to Input-Output Circuits.Frontiers in neural circuits · 2021Review
- Chemogenetic activation of an infralimbic cortex to basolateral amygdala projection promotes resistance to acute social defeat stress.Scientific reports · 2020Article
- Activity of a vmPFC-DRN Pathway Corresponds With Resistance to Acute Social Defeat Stress.Frontiers in neural circuits · 2020Article
- Development of social play in hamsters: Sex differences and their possible functions.Brain research · 2019Article
- Differences in neurotropism and neurotoxicity among retrograde viral tracers.Molecular neurodegeneration · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Stress is a contributing factor in the etiology of several mood and anxiety disorders, and social defeat models are used to investigate the biological basis of stress-related psychopathologies. Male Syrian hamsters are highly aggressive and territorial, but after social defeat they exhibit a conditioned defeat (CD) response which is characterized by increased submissive behavior and a failure to defend their home territory against a smaller, non-aggressive intruder. Hamsters with dominant social status show increased c-Fos expression in the infralimbic (IL) cortex following social defeat and display a reduced CD response at testing compared to subordinates and controls. In this study, we tested the prediction that dominants would show increased defeat-induced neural activity in IL, but not prelimbic (PL) or ventral hippocampus (vHPC), neurons that send efferent projections to the basolateral amygdala (BLA) compared to subordinates. We performed dual immunohistochemistry for c-Fos and cholera toxin B (CTB) and found that dominants display a significantly greater proportion of double-labeled c-Fos + CTB cells in both the IL and PL. Furthermore, dominants display more c-Fos-positive cells in both the IL and PL, but not vHPC, compared to subordinates. These findings suggest that dominant hamsters selectively activate IL and PL, but not vHPC, projections to the amygdala during social defeat, which may be responsible for their reduced CD response. This project extends our understanding of the neural circuits underlying resistance to social stress, which is an important step toward delineating a circuit-based approach for the prevention and treatment of stress-related psychopathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.