ReviewThe Journal of allergy and clinical immunology2019
Lessons learned from the study of human inborn errors of innate immunity.
Review in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Trans-ethnic genome-wide association study of severe COVID-19.Communications biology · 2021Pooled it
- The Hao-Fountain syndrome gene USP7 restricts neurotropic orthoflavivirus entry through cell-intrinsic control of endosomal dynamics.bioRxiv : the preprint server for biology · 2026Article
- Fungal Infections in Disorders of Inborn Errors of Immunity.Clinical reviews in allergy & immunology · 2026Review
- Genes causative of primary immunodeficiency are risk factors for and are over-expressed in systemic lupus erythematosus.Frontiers in immunology · 2026Article
- Review
- Post-Polio Syndrome: Impact of Humoral Immune Deficiencies, Poliovirus Neutralizing Antibodies, Vitamin D Deficiency.Vaccines · 2025Article
- The German Center for Child and Adolescent Health - A new structure for translational research in pediatrics shaping the health of children today and future generations.Molecular and cellular pediatrics · 2025Article
- Spectrum of different categories of Primary Immunodeficiency Disorders diagnosed at Children Hospital.Pakistan journal of medical sciences · 2025Article
- Antiviral immunity lassoed down by excess RNA.The Journal of experimental medicine · 2025Article
- Flow cytometry-based diagnostic approach for inborn errors of immunity: experience from Algeria.Frontiers in immunology · 2024Article
- Inborn errors of immunity with susceptibility toFrontiers in pediatrics · 2024Review
- A novel loss of function mutation in the PHD domain of the RAG2 gene, affecting zinc-binding affinity.Molecular biology reports · 2023Article
- Inborn Error of STAT2-Dependent IFN-I Immunity in a Patient Presented with Hemophagocytic Lymphohistiocytosis and Multisystem Inflammatory Syndrome in Children.Journal of clinical immunology · 2023Article
- Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot study.BMC immunology · 2023Article
- [Principles of the diagnostics of inborn errors of immunity].Zeitschrift fur Rheumatologie · 2023Review
- Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children.The Journal of allergy and clinical immunology · 2023Review
- Serum Allergen-Specific IgE among Pediatric Patients with Primary Immunodeficiency.Children (Basel, Switzerland) · 2022Article
- Is Rituximab-Associated Hypogammaglobulinemia Always Linked to B-Cell Depletion?Children (Basel, Switzerland) · 2022Article
- Host Defenses to Viruses: Lessons from Inborn Errors of Immunity.Medicina (Kaunas, Lithuania) · 2022Review
- Inborn Errors of Immunity With Fetal or Perinatal Clinical Manifestations.Frontiers in pediatrics · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Innate immunity contributes to host defense through all cell types and relies on their shared germline genetic background, whereas adaptive immunity operates through only 3 main cell types, αβ T cells, γδ T cells, and B cells, and relies on their somatic genetic diversification of antigen-specific responses. Human inborn errors of innate immunity often underlie infectious diseases. The range and nature of infections depend on the mutated gene, the deleteriousness of the mutation, and other ill-defined factors. Most known inborn errors of innate immunity to infection disrupt the development or function of leukocytes other than T and B cells, but a growing number of inborn errors affect cells other than circulating and tissue leukocytes. Here we review inborn errors of innate immunity that have been recently discovered or clarified. We highlight the immunologic implications of these errors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.