ArticleAngewandte Chemie (International ed. in English)2018
Thermodynamically Stable, Photoreversible Pharmacology in Neurons with One- and Two-Photon Excitation.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Bidirectional Photoswitching of a Tailored Azobenzene with Red and Far-Red Light Involving Triplet Sensitization in an Aqueous System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Manipulation of Chemistry and Biology with Visible Light Using Tetra-ortho-Substituted Azobenzenes and Azonium Ions.Angewandte Chemie (International ed. in English) · 2025Review
- New tricks and emerging applications from contemporary azobenzene research.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Article
- Two-photon absorption and two-photon-induced isomerization of azobenzene compounds.RSC advances · 2020Review
- Intracellular photoswitchable neuropharmacology driven by luminescence from upconverting nanoparticles.Chemical communications (Cambridge, England) · 2020Article
- Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs.ACS central science · 2019Article
- Iminothioindoxyl as a molecular photoswitch with 100 nm band separation in the visible range.Nature communications · 2019Article
- Locked-Azobenzene: Testing the Scope of a Unique Photoswitchable Scaffold for Cell Physiology.ACS chemical neuroscience · 2019Article
- Holographic two-photon activation for synthetic optogenetics.Nature protocols · 2019Article
- Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation.Nature communications · 2019Article
- Chemical tuning of photoswitchable azobenzenes: a photopharmacological case study using nicotinic transmission.Beilstein journal of organic chemistry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Photoswitchable bioprobes enable bidirectional control of cell physiology with different wavelengths of light. Many current photoswitches use cytotoxic UV light and are limited by the need for constant illumination owing to thermal relaxation in the dark. Now a photoswitchable tetrafluoroazobenzene(4FAB)-based ion channel antagonist has been developed that can be efficiently isomerized in two separate optical channels with visible light. Importantly, the metastable cis configuration showed very high stability in the dark over the course of days at room temperature. In neurons, the 4FAB antagonist reversibly blocks voltage-gated ion channels with violet and green light. Furthermore, photoswitching could also be achieved with two-photon excitation yielding high spatial resolution. 4FAB probes have the potential to enable long-term biological studies where both ON and OFF states can be maintained in the absence of irradiation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.