ArticlePloS one2018
Raman chemical imaging, a new tool in kidney stone structure analysis: Case-study and comparison to Fourier Transform Infrared spectroscopy.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Correlative microscopy for in-depth analysis of calcium oxalate crystals in plant tissues.Plant methods · 2025Article
- Characteristics of urinary stone composition among patients with urolithiasis: a retrospective study in China.BMJ open · 2024Observational
- Kidney stone growth through the lens of Raman mapping.Scientific reports · 2024Article
- Advancements in stone classification: unveiling the beauty of urolithiasis.World journal of urology · 2024Review
- Sample preparation and analysis protocols for the elucidation of structure and chemical distribution in kidney stones.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2024Article
- Physicochemical understanding of biomineralization by molecular vibrational spectroscopy: From mechanism to nature.Exploration (Beijing, China) · 2023Review
- Quantitative Raman chemical imaging of intracellular drug-membrane aggregates and small molecule drug precipitates in cytoplasmic organelles.Advanced drug delivery reviews · 2023Review
- RaMALDI: Enabling simultaneous Raman and MALDI imaging of the same tissue section.Biosensors & bioelectronics · 2023Article
- Chemical Studies of Multicomponent Kidney Stones Using the Modern Advanced Research Methods.Molecules (Basel, Switzerland) · 2023Article
- Article
- Preliminary assessment of a portable Raman spectroscopy system for post-operative urinary stone analysis.World journal of urology · 2022Article
- Nucleation kinetics of calcium oxalate monohydrate as a function of pH, magnesium, and osteopontin concentration quantified with droplet microfluidics.Biomicrofluidics · 2021Article
- Trends in urinary stone composition in 23,182 stone analyses from 2011 to 2019: a high-volume center study in China.World journal of urology · 2021Article
- Human kidney stones: a natural record of universal biomineralization.Nature reviews. Urology · 2021Review
- Multiple Pathways for Pathological Calcification in the Human Body.Advanced healthcare materials · 2021Review
- The surgeon's role on chemical investigations of the composition of urinary stones.Urolithiasis · 2020Article
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6 authors.
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Abstract
BACKGROUND AND
objectivesThe kidney stone's structure might provide clinical information in addition to the stone composition. The Raman chemical imaging is a technology used for the production of two-dimension maps of the constituents' distribution in samples. We aimed at determining the use of Raman chemical imaging in urinary stone analysis. MATERIAL AND
methodsFourteen calculi were analyzed by Raman chemical imaging using a confocal Raman microspectrophotometer. They were selected according to their heterogeneous composition and morphology. Raman chemical imaging was performed on the whole section of stones. Once acquired, the data were baseline corrected and analyzed by MCR-ALS. Results were then compared to the spectra obtained by Fourier Transform Infrared spectroscopy.
resultsRaman chemical imaging succeeded in identifying almost all the chemical components of each sample, including monohydrate and dihydrate calcium oxalate, anhydrous and dihydrate uric acid, apatite, struvite, brushite, and rare chemicals like whitlockite, ammonium urate and drugs. However, proteins couldn't be detected because of the huge autofluorescence background and the small concentration of these poor Raman scatterers. Carbapatite and calcium oxalate were correctly detected even when they represented less than 5 percent of the whole stones. Moreover, Raman chemical imaging provided the distribution of components within the stones: nuclei were accurately identified, as well as thin layers of other components. Conversion of dihydrate to monohydrate calcium oxalate was correctly observed in the centre of one sample. The calcium oxalate monohydrate had different Raman spectra according to its localization.
conclusionRaman chemical imaging showed a good accuracy in comparison with infrared spectroscopy in identifying components of kidney stones. This analysis was also useful in determining the organization of components within stones, which help locating constituents in low quantity, such as nuclei. However, this analysis is time-consuming, making it more suitable for research studies rather than routine analysis.
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