ArticleMicrobial genomics2018
Characterization of capsule genes in non-pathogenic Neisseria species.
Article in Microbial genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Analysis of the Facial Skin Bacterial Community in Vietnamese Individuals with Sensitive Skin and Clinical Relevance.Dermatology and therapy · 2026Article
- Direct whole-genome sequencing enables strain typing of unculturableMicrobial genomics · 2025Article
- Regulation of the promoter for capsular polysaccharide synthesis inMicrobiology spectrum · 2025Article
- Review
- Colonization Rate and Associated Factors of Non-PathogenicInfection and drug resistance · 2023Article
- Global genomic and proteomic analysis indicates co-evolution of Neisseria species and with their human host.World journal of microbiology & biotechnology · 2022Article
- Neisseria genes required for persistence identified via in vivo screening of a transposon mutant library.PLoS pathogens · 2022Article
- Impact of Helicobacter pylori infection on fluid duodenal microbial community structure and microbial metabolic pathways.BMC microbiology · 2022Article
- Type VI secretion system killing by commensaleLife · 2021Article
- Analysis of the Bacterial Flora of Sensitive Facial Skin Among Women in Guangzhou.Clinical, cosmetic and investigational dermatology · 2021Article
- Lung abscess due to Neisseria meningitidis serogroup X-unexpected virulence of a commensal resulting from putative serogroup B capsular switching.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Virulence genes and previously unexplored gene clusters in four commensalMicrobial genomics · 2020Article
- Neisseria meningitidis: using genomics to understand diversity, evolution and pathogenesis.Nature reviews. Microbiology · 2020Review
- Two Cases of Newly Characterized Neisseria Species, Brazil.Emerging infectious diseases · 2020Article
- Genetic determinants of genus-level glycan diversity in a bacterial protein glycosylation system.PLoS genetics · 2019Article
- Gauging the epidemic potential of a widely circulating non-invasive meningococcal strain in Africa.Microbial genomics · 2019Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The genus Neisseria comprises a diverse group of commensal bacteria, which typically colonize the mucosal surfaces of humans and other animals. Neisseria meningitidis, the meningococcus, is notable for its potential to cause invasive meningococcal disease (IMD) in humans; however, IMD is comparatively rare, and meningococci normally colonize the nasopharynx asymptomatically. Possession of a polysaccharide capsule has been shown to be a prerequisite for disease in almost all IMD cases, and was previously considered unique to N. meningitidis, and potentially acquired by horizontal genetic transfer (HGT). Nevertheless, the capsule must also have some role in asymptomatic colonization and/or transmission, consistent with the existence of six non-disease-associated meningococcal capsule serogroups. In this study, full complements of putative capsule genes were identified in non-pathogenic Neisseria species, including Neisseria subflava and Neisseria elongata. These species contained genes for capsule transport and translocation homologous to those of N. meningitidis, as well as novel putative capsule synthesis genes. Phylogenetic analyses were consistent with the proposal that these genes were acquired by the meningococcus through HGT. In contrast with previous evolutionary models, however, the most parsimonious explanation of these data was that capsule transport genes had been lost in the common ancestor of the meningococcus, gonococcus, and their close relatives, and then reacquired by some meningococci. The most likely donor of the meningococcal transport genes was another Neisseria species.
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