Evidence map›Paper›PMID 30074270›Full record

ArticleJournal of cellular biochemistry2018

Protein kinase Cε targets respiratory chain and mitochondrial membrane potential but not F

Grazyna Nowak, Diana Bakajsova-Takacsova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The Role of Host-Generated HFrontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Grazyna NowakDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas.ORCID 0000-0002-8961-6869
Diana Bakajsova-TakacsovaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR029884 · NCRR · UNIV OF ARKANSAS FOR MED SCIS · PI LOWERY, CURTIS L · 2009 to 2011
$11.4M
Protein Kinase C in the Repair of Cellular FunctionsR01DK059558 · NIDDK · UNIV OF ARKANSAS FOR MED SCIS · PI NOWAK, GRAZYNA · 2001 to 2013
$2.6M
NCRR NIH HHS UL1 RR029884NIDDK NIH HHS R01 DK059558
6 · The paper itself

Abstract

We have previously shown that protein kinase Cε (PKCε) is involved in mitochondrial dysfunction in renal proximal tubular cells (RPTC). This study examined mitochondrial targets of active PKCε in RPTC injured by the model oxidant tert-butyl hydroperoxide (TBHP). TBHP exposure augmented the levels of phosphorylated (active) PKCε in mitochondria, which suggested translocation of PKCε to mitochondria after oxidant exposure. Oxidant injury decreased state 3 respiration, adenosine triphosphate (ATP) production, ATP content, and complex I activity. Further, TBHP exposure increased ΔΨ

Indexed as

AnimalsApoptosisElectron TransportElectron Transport Complex IElectron Transport Complex IVFemaleKidneyL-Lactate DehydrogenaseMembrane Potential, MitochondrialMitochondriaOxidantsProtein Kinase C-epsilonProton-Translocating ATPasesRabbitsReactive Oxygen SpeciesElectron Transport Complex IElectron Transport Complex IVL-Lactate DehydrogenaseOxidantsProtein Kinase C-epsilonProton-Translocating ATPasesReactive Oxygen Speciesadenosine triphosphate synthasemitochondriamitochondrial membrane potentialoxidant injuryprotein kinase Cεreactive oxygen speciesrenal proximal tubular cellsrespiratory chain

Identifiers

PMID30074270
PMCPMC6298597

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.