Evidence map›Paper›PMID 30074228›Full record

ArticleTranslational stroke research2019

The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke.

Wenshu Luo, Tao Liu, Shanshan Li, Hongmei Wen, Fenghua Zhou, Ross Zafonte, Xun Luo, Minghzu Xu, Randie Black-Schaffer, Lisa J Wood and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Observational
  6. Review
  7. Observational
  8. Article
  9. FNDC5/Irisin in dementia and cognitive impairment: update and novel perspective.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Materials to Promote Recovery After Stroke.Current opinion in biomedical engineering · 2020
    Article
  19. Effect of black chokeberry on skeletal muscle damage and neuronal cell death.Journal of exercise nutrition & biochemistry · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Wenshu LuoStroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, the teaching affiliate of Harvard Medical School, Charlestown, MA, 02129, USA.
Tao LiuStroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, the teaching affiliate of Harvard Medical School, Charlestown, MA, 02129, USA.
Shanshan LiStroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, the teaching affiliate of Harvard Medical School, Charlestown, MA, 02129, USA.
Hongmei WenStroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, the teaching affiliate of Harvard Medical School, Charlestown, MA, 02129, USA.
Fenghua ZhouStroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, the teaching affiliate of Harvard Medical School, Charlestown, MA, 02129, USA.
Ross ZafonteDepartments of Physical Medicine & Rehabilitation, Harvard Medical School/Spaulding Rehabilitation Hospital Network, Brigham and Women's Hospital, and Massachusetts General Hospital, Boston, MA, USA.
Xun LuoKerry Rehabilitation Medicine Research Institute, Shenzhen, 518048, Guangdong, China.
Minghzu XuStroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, the teaching affiliate of Harvard Medical School, Charlestown, MA, 02129, USA.
Randie Black-SchafferDepartments of Physical Medicine & Rehabilitation, Harvard Medical School/Spaulding Rehabilitation Hospital Network, Brigham and Women's Hospital, and Massachusetts General Hospital, Boston, MA, USA.
Lisa J WoodSchool of Nursing, MGH Institute of Health Professions, Charlestown, MA, 02129, USA.
Yulong WangThe First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, Guangdong, China. ylwang66@126.com.
Qing Mei WangStroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, the teaching affiliate of Harvard Medical School, Charlestown, MA, 02129, USA. wang.qingmei@mgh.harvard.edu.ORCID 0000-0003-4655-4917
Harvard University · USBrigham and Women's Hospital · USMGH Institute of Health Professions · USRutgers, The State University of New Jersey · USShenzhen Second People's Hospital · CN

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
National Center for Advancing Translational Sciences UL1 TR001102NCATS NIH HHS UL1 TR001102
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) plays an important role in neuroplasticity and neurogenesis following ischemic and non-ischemic brain injury. The predictive value of BDNF for short-term outcome after stroke is controversial. The objective of this study was to investigate the relationship among serum BDNF level, fractional anisotropy (FA), and functional outcome during post-acute stroke rehabilitation. Serum BDNF levels were measured on admission to an acute inpatient rehabilitation hospital. The primary functional outcome was functional independence measure (FIM) motor subscore at discharge. The secondary outcome measures were FIM total score at discharge, FIM motor subscore on admission, length of stay in the hospital, and discharge destination. We investigated the relationship among the level of serum BDNF and FA as well as functional outcome measures. Three hundred forty-eight consecutive stroke subjects were included in the analysis. Serum BDNF levels on admission were statistically but not clinically correlated with FIM motor subscore at discharge (r = 0.173, P = 0.001) and FIM total score at discharge (r = 0.155, P = 0.004). Receiver operating characteristic (ROC) analysis of BDNF as a predictor for FIM motor subscore improvement showed low accuracy of prediction with an area under the curve (AUC) of 0.581 (P = 0.026). Serum BDNF significantly correlated with FA in the high FIM motor group (n = 10, r = 0.609, P = 0.031) but not in the low FIM motor group (n = 11, r = - 0.132, P = 0.349). The serum BDNF level alone offers minimum predictive value for recovery of motor function during post-acute rehabilitation. Our findings suggest that serum BDNF level may be correlated with FA.

Indexed as

Stroke RehabilitationAgedAged, 80 and overBiomarkersBrain-Derived Neurotrophic FactorFemaleHumansMaleMiddle AgedMotor SkillsPredictive Value of TestsRecovery of FunctionStrokeBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorBDNF (brain-derived neurotrophic factor)FA (fractional anisotropy)FIM (functional independence measure)Stroke rehabilitation

Identifiers

PMID30074228
PMCPMC6391224
OpenAlexW2887009538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.