ArticleCurrent medical science2018
Fusarium solani Activates Dectin-1 in Experimentally Induced Keratomycosis.
Article in Current medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- C-Type lectin receptors as key modulators of intestinal inflammation: insights into IBD pathogenesis and therapy.FEMS microbiology letters · 2026Review
- Interaction Between Glycoside Hydrolase FsGH28c fromInternational journal of molecular sciences · 2025Article
- Aspergillus fumigatus Hypoxia Adaptation Is Critical for the Establishment of Fungal Keratitis.Investigative ophthalmology & visual science · 2024Article
- Dectin-1 participates in the immune-inflammatory response to mouseFrontiers in immunology · 2024Article
- Immunologic mechanism of fungal keratitis.International journal of ophthalmology · 2021Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, the response of Dectin-1 on macrophages to Fusarium solani (F. solani) and the expression patterns of Dectin-1 in experimentally F. solani-induced keratomycosis were investigated. Peritoneal macrophages isolated after intraperitoneal injection of sodium thioglycollate were co-cultured with laminarin and spores of F. solani for 12 h. The expression levels of Dectin-1 and CARD9 were detected by immunofluorescence and real-time quantitative polymerase chain reaction. A mouse model of fungal keratitis was established by substromal inoculation with spores of F. solani. Corneal lesions and inflammatory responses were observed by slit-lamp and histopathology at 1, 2, 3, 5, and 7 day(s) after infection. Dectin-1 expression was significantly upregulated on macrophages stimulated by spores of F. solani. Dectin-1 was not detected in normal corneas of C57BL/6 mice, but detected in infected corneas from the first day after inoculation, with high mRNA levels observed on days 2 and 3. CARD9, a key transducer of Dectin-1 signaling, was also upregulated in infected corneas. In conclusion, Dectin-1 is an important recognition receptor in F. solani-induced keratitis, but the molecular mechanisms warrant further investigation.
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