Evidence map›Paper›PMID 30074131›Full record

ArticleJournal of assisted reproduction and genetics2018

Pre-implantation genetic testing: decisional factors to accept or decline among in vitro fertilization patients.

Brandy Lamb, Erin Johnson, Leslie Francis, Melinda Fagan, Naomi Riches, Isabella Canada, Alena Wilson, Amber Mathiesen, Maya Sabatello, Shawn Gurtcheff and 2 more

Abstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Does theFMR1 gene affect IVF success?Reproductive biomedicine online · 2019
    Pooled it
  2. Review
  3. In vitro fertilization as an option for couples with genetic disorders.Clinical and experimental reproductive medicine · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Addressing ethical issues related to prenatal diagnostic procedures.Maternal health, neonatology and perinatology · 2023
    Article
  8. Article
  9. Article
  10. Patient perspectives and experiences withTherapeutic advances in reproductive health
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Brandy LambUniversity of Utah, 10 South 2000 East, Salt Lake City, UT, USA.
Erin JohnsonUniversity of Utah, 10 South 2000 East, Salt Lake City, UT, USA.
Leslie FrancisUniversity of Utah, 10 South 2000 East, Salt Lake City, UT, USA.
Melinda FaganUniversity of Utah, 10 South 2000 East, Salt Lake City, UT, USA.
Naomi RichesUniversity of Utah, 10 South 2000 East, Salt Lake City, UT, USA.
Isabella CanadaUniversity of Utah, 10 South 2000 East, Salt Lake City, UT, USA.
Alena WilsonUniversity of Utah, 10 South 2000 East, Salt Lake City, UT, USA.
Amber MathiesenUniversity of Utah, 10 South 2000 East, Salt Lake City, UT, USA.
Maya SabatelloColumbia University, New York, NY, USA.
Shawn GurtcheffUtah Fertility Clinic, Pleasant Grove, UT, USA.
Erica JohnstoneUniversity of Utah, 10 South 2000 East, Salt Lake City, UT, USA.
Erin RothwellUniversity of Utah, 10 South 2000 East, Salt Lake City, UT, USA. erin.rothwell@nurs.utah.edu.ORCID http://orcid.org/0000-0002-2294-2299

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
Utah Center of Excellence in ELSI Research: UCEERRM1HG009037 · NHGRI · UNIVERSITY OF UTAH · PI ROTHWELL, ERIN, TABERY, JAMES · 2016 to 2024
$8.0M
Impact of Psychiatric Genetic Data on Civil Litigation and its Relationship with StigmaK01HG008653 · NHGRI · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI SABATELLO, MAYA · 2015 to 2019
$871k
NCATS NIH HHS 1UL1TR001067NCATS NIH HHS UL1 TR001067NCATS NIH HHS UL1 TR002538NHGRI NIH HHS HG009037NHGRI NIH HHS K01 HG008653NHGRI NIH HHS RM1 HG009037
6 · The paper itself

Abstract

purposeEmbryo testing to improve pregnancy outcomes among individuals who are seeking assisted reproduction technologies is increasing. The purpose of this study was to assess decisional factors through in-depth interviews for why women would accept or decline preimplantation genetic testing for aneuploidy (PGT-A) with in vitro fertilization (IVF).

methodsSemi-structured telephone interviews were conducted with 37 women who were offered PGT-A with IVF during the summer 2017. Interviews lasted on average 40 min and were audio-recorded, transcribed, and analyzed using a content analysis.

resultsResults identified a number of decisional factors related to values about conception, disability, and pregnancy termination, past pregnancy experiences, optimism toward technology, and cost. Other key issues that were identified include the use of expanded carrier screening prior to IVF, maternal age, and limited education about PGT-A due to the complexity about education for IVF alone.

conclusionThere is a need to develop decision support tools for the increasing choices of genetic testing options for patients seeking IVF. Including patients' values, past pregnancy experiences and attitudes toward science into the decision-making process may help promote a more informed decision.

Indexed as

AneuploidyDecision MakingEmbryo ImplantationFemaleFertilization in VitroGenetic TestingHumansMaternal AgePregnancyPregnancy OutcomePreimplantation DiagnosisReproductive Techniques, AssistedDecision makingInterviewsIn vitro fertilization (IVF)Preimplantation genetic screening (PGS)Preimplantation genetic testing for aneuploidy (PGT-A)

Identifiers

PMID30074131
PMCPMC6133803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.