ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019
Human non-REM sleep and the mean global BOLD signal.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Simultaneous EEG-PET-MRI identifies temporally coupled and spatially structured brain dynamics across wakefulness and NREM sleep.Nature communications · 2025Article
- Amplitude fluctuations of cerebrovascular oscillations and CSF movement desynchronize during NREM3 sleep.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness.Communications biology · 2025Article
- Modulate the impact of the drowsiness on the resting state functional connectivity.Scientific reports · 2024Article
- Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease.Brain : a journal of neurology · 2023Article
- Sleep fMRI with simultaneous electrophysiology at 9.4 T in male mice.Nature communications · 2023Article
- Cerebrovascular activity is a major factor in the cerebrospinal fluid flow dynamics.NeuroImage · 2022Article
- Contribution of animal models toward understanding resting state functional connectivity.NeuroImage · 2021Review
- Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease-related pathology.PLoS biology · 2021Article
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- Vigilance Effects in Resting-State fMRI.Frontiers in neuroscience · 2020Review
- Unstable wakefulness during resting-state fMRI and its associations with network connectivity and affective psychopathology in young adults.Journal of affective disorders · 2019Article
- Sympathetic activity contributes to the fMRI signal.Communications biology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
A hallmark of non-rapid eye movement (REM) sleep is the decreased brain activity as measured by global reductions in cerebral blood flow, oxygen metabolism, and glucose metabolism. It is unknown whether the blood oxygen level dependent (BOLD) signal undergoes similar changes. Here we show that, in contrast to the decreases in blood flow and metabolism, the mean global BOLD signal increases with sleep depth in a regionally non-uniform manner throughout gray matter. We relate our findings to the circulatory and metabolic processes influencing the BOLD signal and conclude that because oxygen consumption decreases proportionately more than blood flow in sleep, the resulting decrease in paramagnetic deoxyhemoglobin accounts for the increase in mean global BOLD signal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.