Evidence map›Paper›PMID 30073456›Full record

ReviewEndocrine2018

Adrenocortical incidentalomas and bone: from molecular insights to clinical perspectives.

Barbara Altieri, Giovanna Muscogiuri, Stavroula A Paschou, Andromachi Vryonidou, Silvia Della Casa, Alfredo Pontecorvi, Martin Fassnacht, Cristina L Ronchi, John Newell-Price

Erratum issuedOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Endocrine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Barbara AltieriDivision of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg, Germany. altieri.barbara@gmail.com.ORCID http://orcid.org/0000-0003-2616-3249
Giovanna MuscogiuriDepartment of Clinical Medicine and Surgery, University "Federico II", Naples, Italy.ORCID http://orcid.org/0000-0002-8809-4931
Stavroula A PaschouDivision of Endocrinology and Diabetes, "Aghia Sophia" Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID http://orcid.org/0000-0002-0651-1376
Andromachi VryonidouDepartment of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece.
Silvia Della CasaDivision of Endocrinology and Metabolic Diseases, Institute of Medical Pathology, Catholic University of the Sacred Heart, Rome, Italy.ORCID http://orcid.org/0000-0002-1245-753X
Alfredo PontecorviDivision of Endocrinology and Metabolic Diseases, Institute of Medical Pathology, Catholic University of the Sacred Heart, Rome, Italy.ORCID http://orcid.org/0000-0003-0570-6865
Martin FassnachtDivision of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg, Germany.ORCID http://orcid.org/0000-0001-6170-6398
Cristina L RonchiDivision of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg, Germany.ORCID http://orcid.org/0000-0001-5020-2071
John Newell-PriceDepartment of Oncology and Metabolism, University of Sheffield Medical School, Sheffield, UK.ORCID http://orcid.org/0000-0002-0835-5493
Università Cattolica del Sacro Cuore · ITFederico II University Hospital · ITHellenic Red Cross · GRNational and Kapodistrian University of Athens · GRUniversity of Birmingham · GBUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adrenal incidentalomas constitute a common clinical problem with an overall prevalence of around 2-3%, but are more common with advancing age being present in 10% of those aged 70 years. The majority of these lesions are benign adrenocortical adenomas (80%), characterized in 10-40% of the cases by autonomous cortisol hypersecretion, and in 1-10% by aldosterone hypersecretion. Several observational studies have shown that autonomous cortisol and aldosterone hypersecretion are more prevalent than expected in patients with osteopenia and osteoporosis: these patients have accelerated bone loss and an increased incidence of vertebral fractures. In contrast to glucocorticoid action, the effects of aldosterone on bone are less well understood. Recent data, demonstrating a concomitant co-secretion of glucocorticoid metabolites in patients with primary aldosteronism, could explain some of the metabolic abnormalities seen in patients with aldosterone hypersecretion. In clinical practice, patients with unexplained osteoporosis, particularly when associated with other features such as impaired glucose tolerance or hypertension, should be investigated for the possible presence of autonomous cortisol or aldosterone secretion due to an adrenal adenoma. Randomized intervention studies are needed, however, to investigate the optimum interventions for osteoporosis and other co-morbidities in these patients.

Indexed as

Adrenal Gland NeoplasmsAdrenocortical AdenomaBone and BonesHumansAdrenalAutonomous cortisol hypersecretionBoneIncidentalomaOsteoporosisPrimary aldosteronism

Identifiers

PMID30073456
OpenAlexW2885096707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.