ArticleAnnals of intensive care2018
Respiratory changes of the inferior vena cava diameter predict fluid responsiveness in spontaneously breathing patients with cardiac arrhythmias.
Article in Annals of intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Respiratory Variations of the Inferior Vena Cava and Femoral Artery Flow to Predict Fluid Responsiveness in Spontaneously Breathing Patients With Sepsis, Acute Circulatory Failure, and Regular Cardiac Rhythm
Comparison of Transhepatic and Subcostal Views for Assessing Inferior Vena Cava Diameter Variation in Cardiac Surgery Patients
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Pooled it
- Ultrasound dynamic monitoring of IVCD to guide application of CRRT in patients with renal failure combined with acute heart failure.Scientific reports · 2022Trial
- Ultrasound-Guided Mini Fluid Challenge via Velocity-Time Integral to Assess Fluid Responsiveness in Upper Gastrointestinal Bleeding: A Prospective Quasi-Experimental Feasibility Study.Life (Basel, Switzerland) · 2026Article
- Validation of the inferior vena cava collapsibility as a predictive marker of fluid responsiveness in spontaneously breathing patients.Scientific reports · 2026Article
- Early detection of hypovolemia by venous pulse wave velocity and vena cava ultrasound imaging.European journal of applied physiology · 2026Article
- Article
- Observational
- Assessment of Fluid Responsiveness via Central Venous Ultrasound Measurement: A Network Meta-Analysis.Journal of clinical medicine · 2025Review
- Predicting fluid responsiveness in spontaneously breathing parturients undergoing caesarean section via carotid artery blood flow and velocity time integral measured by carotid ultrasound: a prospective cohort study.BMC pregnancy and childbirth · 2024Article
- Inferior vena cava ultrasound and other techniques for assessment of intravascular and extravascular volume: an update.Clinical kidney journal · 2023Review
- Comparison of inferior vena cava collapsibility and central venous pressure in assessing volume status in shocked patients.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2022Article
- Automated versus manual B-lines counting, left ventricular outflow tract velocity time integral and inferior vena cava collapsibility index in COVID-19 patients.Indian journal of anaesthesia · 2022Article
- Diagnostic Accuracy of Ultrasonographic Respiratory Variation in the Inferior Vena Cava, Subclavian Vein, Internal Jugular Vein, and Femoral Vein Diameter to Predict Fluid Responsiveness: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2021Article
- Ultrasound Assessment of the Inferior Vena Cava for Fluid Responsiveness: Making the Case for Skepticism.Journal of intensive care medicine · 2021Article
- Predicting fluid responsiveness in non-intubated COVID-19 patients: two methods are better than one.Annals of intensive care · 2021Article
- The POCUS Consult: How Point of Care Ultrasound Helps Guide Medical Decision Making.International journal of general medicine · 2021Review
- Measurement site of inferior vena cava diameter affects the accuracy with which fluid responsiveness can be predicted in spontaneously breathing patients: a post hoc analysis of two prospective cohorts.Annals of intensive care · 2020Article
- Performance of a 25% Inferior Vena Cava Collapsibility in Detecting Fluid Responsiveness When Assessed by Novice Versus Expert Physician Sonologists.Journal of intensive care medicine · 2020Observational
- Association of inferior vena cava diameter ratio measured on computed tomography scans with the outcome of patients with septic shock.Medicine · 2020Observational
- Prediction of fluid responsiveness in spontaneously breathing patients.Annals of translational medicine · 2020Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhether the respiratory changes of the inferior vena cava diameter during a deep standardized inspiration can reliably predict fluid responsiveness in spontaneously breathing patients with cardiac arrhythmia is unknown.
methodsThis prospective two-center study included nonventilated arrhythmic patients with infection-induced acute circulatory failure. Hemodynamic status was assessed at baseline and after a volume expansion of 500 mL 4% gelatin. The inferior vena cava diameters were measured with transthoracic echocardiography using the bi-dimensional mode on a subcostal long-axis view. Standardized respiratory cycles consisted of a deep inspiration with concomitant control of buccal pressures and passive exhalation. The collapsibility index of the inferior vena cava was calculated as [(expiratory-inspiratory)/expiratory] diameters.
resultsAmong the 55 patients included in the study, 29 (53%) were responders to volume expansion. The areas under the ROC curve for the collapsibility index and inspiratory diameter of the inferior vena cava were both of 0.93 [95% CI 0.86; 1]. A collapsibility index ≥ 39% predicted fluid responsiveness with a sensitivity of 93% and a specificity of 88%. An inspiratory diameter < 11 mm predicted fluid responsiveness with a sensitivity of 83% and a specificity of 88%. A correlation between the inspiratory effort and the inferior vena cava collapsibility was found in responders but was absent in nonresponder patients.
conclusionsIn spontaneously breathing patients with cardiac arrhythmias, the collapsibility index and inspiratory diameter of the inferior vena cava assessed during a deep inspiration may be noninvasive bedside tools to predict fluid responsiveness in acute circulatory failure related to infection. These results, obtained in a small and selected population, need to be confirmed in a larger-scale study before considering any clinical application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.