Evidence map›Paper›PMID 30073198›Full record

ArticleeNeuro

Nausea-Induced 5-HT Release in the Interoceptive Insular Cortex and Regulation by Monoacylglycerol Lipase (MAGL) Inhibition and Cannabidiol.

Cheryl L Limebeer, Erin M Rock, Keith A Sharkey, Linda A Parker

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Endocannabinoid signaling in stress, nausea, and vomiting.Neurogastroenterology and motility · 2025
    Review
  4. The Polypharmacological Effects of Cannabidiol.Molecules (Basel, Switzerland) · 2023
    Review
  5. Review
  6. Cannabidiol Interferes with Establishment of ΔCannabis and cannabinoid research · 2022
    Article
  7. Review
  8. Cannabinoids and Cancer Chemotherapy-Associated Adverse Effects.Journal of the National Cancer Institute. Monographs · 2021
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Pathogens, odors, and disgust in rodents.Neuroscience and biobehavioral reviews · 2020
    Review
  14. Article
  15. Antiemetic Effects of Cannabinoid Agonists in Nonhuman Primates.The Journal of pharmacology and experimental therapeutics · 2020
    Article
  16. Article
  17. Article
  18. Review
  19. Effect of combined doses of ΔPsychopharmacology · 2020
    Article
  20. The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cheryl L LimebeerDepartment of Psychology and Neuroscience Program, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Erin M RockDepartment of Psychology and Neuroscience Program, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Keith A SharkeyHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Linda A ParkerDepartment of Psychology and Neuroscience Program, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
University of Guelph · CAUniversity of Calgary · CA

Funding

CIHR 323932CIHR 340889CIHR 388239
6 · The paper itself

Abstract

Using the rat conditioned gaping model of nausea, the interoceptive insular cortex (IIC) has been identified as a critical site for the regulation of lithium chloride (LiCl)-induced nausea. Indirect evidence supports a model where serotonin (5-HT) acts on postsynaptic 5-HT

Indexed as

Cerebral CortexInteroceptionNauseaAnimalsCannabidiolCarbamatesDisease Models, AnimalLithium ChlorideMaleMonoacylglycerol LipasesRatsRats, Sprague-DawleySerotoninSerotonin 5-HT3 Receptor AgonistsSerotonin 5-HT3 Receptor AntagonistsSuccinimidesCannabidiolCarbamatesLithium ChlorideMJN110Monoacylglycerol LipasesSerotoninSerotonin 5-HT3 Receptor AgonistsSerotonin 5-HT3 Receptor AntagonistsSuccinimidescannabinoidinteroceptive insular cortexmicrodialysisnausearatserotonin

Identifiers

PMID30073198
PMCPMC6071201
OpenAlexW2887612393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.