Evidence map›Paper›PMID 30073191›Full record

ArticleeNeuro

Examining the Reversibility of Long-Term Behavioral Disruptions in Progeny of Maternal SSRI Exposure.

Susan E Maloney, Shyam Akula, Michael A Rieger, Katherine B McCullough, Krystal Chandler, Adrian M Corbett, Audrey E McGowin, Joseph D Dougherty

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  4. Extensive characterization of a Williams Syndrome murine model showsbioRxiv : the preprint server for biology · 2023
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  10. Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link.International journal of molecular sciences · 2020
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Erroneous inference based on a lack of preference within one group: Autism, mice, and the social approach task.Autism research : official journal of the International Society for Autism Research · 2019
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Susan E MaloneyDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-5585-4722
Shyam AkulaDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-2334-591X
Michael A RiegerDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Katherine B McCulloughDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Krystal ChandlerDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Adrian M CorbettDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435.ORCID 0000-0002-9876-8071
Audrey E McGowinDepartment of Chemistry, Wright State University, Dayton, OH 45435.
Joseph D DoughertyDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-6385-3997
Washington University in St. Louis · USWright State University · US

Funding

Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1M
Serotonin, Autism, and investigating cell types for CNS disorders.R00NS067239 · NINDS · WASHINGTON UNIVERSITY · PI DOUGHERTY, JOSEPH D · 2011 to 2013
$732k
NICHD NIH HHS U54 HD087011NINDS NIH HHS R00 NS067239
6 · The paper itself

Abstract

Serotonergic dysregulation is implicated in numerous psychiatric disorders. Serotonin plays widespread trophic roles during neurodevelopment; thus perturbations to this system during development may increase risk for neurodevelopmental disorders. Epidemiological studies have examined association between selective serotonin reuptake inhibitor (SSRI) treatment during pregnancy and increased autism spectrum disorder (ASD) risk in offspring. It is unclear from these studies whether ASD susceptibility is purely related to maternal psychiatric diagnosis, or if treatment poses additional risk. We sought to determine whether maternal SSRI treatment alone or in combination with genetically vulnerable background was sufficient to induce offspring behavior disruptions relevant to ASD. We exposed C57BL/6J or

Indexed as

Autism Spectrum DisorderPrenatal Exposure Delayed EffectsSocial BehaviorAge FactorsAnimalsBehavior, AnimalCELF ProteinsDisease Models, AnimalFemaleFluoxetineMaleMiceMice, Inbred C57BLPregnancySelective Serotonin Reuptake InhibitorsCelf6 protein, mouseCELF ProteinsFluoxetineSelective Serotonin Reuptake Inhibitorsautismfluoxetinesensory sensitivityserotoninsocial behaviorSSRI

Identifiers

PMID30073191
PMCPMC6071194
OpenAlexW2810253066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.