ArticleBMJ open gastroenterology2018
Growth patterns of colorectal cancer liver metastases and their impact on prognosis: a systematic review.
Article in BMJ open gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- The prognostic significance of histopathological growth patterns in liver metastases undergoing surgery: a systematic review and meta-analysis.Clinical & experimental metastasis · 2025Pooled it
- Histopathologic growth patterns as prognostic factor for survival in patients with colorectal liver metastases.Radiology and oncology · 2026Article
- Deciphering the liver's role in pancreatic cancer metastasis: pathways and therapeutic approaches.NPJ precision oncology · 2025Review
- Clinicopathological insights and management of liver metastases: Current advances and future perspectives.World journal of hepatology · 2025Review
- Article
- The Determinants of Long-Term Outcomes After Colorectal Cancer Surgery: A Literature Review.Cureus · 2024Review
- Histopathological Growth Patterns Determine the Outcomes of Colorectal Cancer Liver Metastasis Following Liver Resection.Cancers · 2024Article
- What's in a name? Refining the nomenclature of liver metastases growth patterns by changing "desmoplastic" to "encapsulated".BJC reports · 2023Article
- Article
- An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.Nature communications · 2023Article
- Mapping Tumor Heterogeneity via Local Entropy Assessment: Making Biomarkers Visible.Journal of digital imaging · 2023Article
- Colorectal liver metastases patients prognostic assessment: prospects and limits of radiomics and radiogenomics.Infectious agents and cancer · 2023Review
- Role of stereotactic body radiotherapy in multidisciplinary management of liver metastases in patients with colorectal cancer.Japanese journal of radiology · 2022Review
- ASO Author Reflections: The Histopathological Growth Pattern of Colorectal Liver Metastases: A New Biomarker to Drive Surgical Strategy.Annals of surgical oncology · 2022Article
- Laparoscopic liver resection for colorectal liver metastases: retrospective analysis of prognostic factors and oncological outcomes in a single-center cohort.Langenbeck's archives of surgery · 2022Article
- The Histopathological Growth Pattern of Colorectal Liver Metastases Impacts Local Recurrence Risk and the Adequate Width of the Surgical Margin.Annals of surgical oncology · 2022Article
- Radiomics and Machine Learning Analysis Based on Magnetic Resonance Imaging in the Assessment of Colorectal Liver Metastases Growth Pattern.Diagnostics (Basel, Switzerland) · 2022Article
- Is precision medicine for colorectal liver metastases still a utopia? New perspectives by modern biomarkers, radiomics, and artificial intelligence.World journal of gastroenterology · 2022Review
- Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern.Cancers · 2022Article
- Tumor vessel co-option: The past & the future.Frontiers in oncology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer liver metastases (CRLM) grow in distinct histological patterns that have been associated with outcome after surgical resection. We conducted a systematic review to evaluate the frequency of different CRLM growth patterns and their impact on prognosis.
methodsWe searched Embase and MEDLINE databases from inception to 1 December 2017 to identify studies that reported CRLM growth pattern histopathology, their frequencies, and/or data related to outcome.
resultsWe included a total of 23 studies (2432 patients with CRLM) published between 1991 and 2017. There were variations in the terminology used to describe the growth patterns as well as in their histopathological definitions. A 'desmoplastic' pattern was most frequently considered, followed by 'pushing' and 'replacement' patterns. Data supported the presence of both intralesional and interlesional heterogeneity. There were no differences in growth pattern distribution stratified by chemotherapy. While heterogeneity of histopathology assessment precluded formal meta-analysis, the majority of articles found favourable outcomes for desmoplastic and unfavourable outcomes for replacement CRLM, independently of when the study was conducted.
conclusionsThe results suggest that CRLM growth patterns may have prognostic potential and that they may be considered for standardised routine histopathological reporting. Further understanding of the different growth patterns may provide important insights into the biological mechanisms that underlie metastatic growth in the liver.
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