Evidence map›Paper›PMID 30072987›Full record

ReviewFrontiers in immunology2018

Expression and Function of Tetraspanins and Their Interacting Partners in B Cells.

Fagui Zou, Xu Wang, Xinxin Han, Gerson Rothschild, Song Guo Zheng, Uttiya Basu, Jianbo Sun

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 67 citations in OpenAlex.

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  9. A Panoramic View of Cell Population Dynamics in Mammalian Aging.bioRxiv : the preprint server for biology · 2024
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  10. Review
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  16. TACI and endogenous APRIL in B cell maturation.Clinical immunology (Orlando, Fla.) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Fagui ZouGuanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China.
Xu WangGuanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China.
Xinxin HanGuanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China.
Gerson RothschildDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
Song Guo ZhengDepartment of Medicine, Milton S. Hershey Medical Center at Penn State University, Pennsylvania, PA, United States.
Uttiya BasuDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
Jianbo SunGuanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China.
Columbia University · USStomatology Hospital · CNSun Yat-sen University · CNHospital of Stomatology, Sun Yat-sen University

Funding

Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination and Somatic HypermutationR01AI099195 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2012 to 2026
$9.8M
Long noncoding RNA expressing genomic element that control antibody diversification and chromosomal integrity in B cellsR01AI134988 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2018 to 2026
$4.7M
NIAID NIH HHS R01 AI099195NIAID NIH HHS R01 AI134988
6 · The paper itself

Abstract

Tetraspanins are transmembrane proteins that modulate multiple diverse biological processes, including signal transduction, cell-cell communication, immunoregulation, tumorigenesis, cell adhesion, migration, and growth and differentiation. Here, we provide a systematic review of the involvement of tetraspanins and their partners in the regulation and function of B cells, including mechanisms associated with antigen presentation, antibody production, cytokine secretion, co-stimulator expression, and immunosuppression. Finally, we direct our focus to the signaling mechanisms, evolutionary conservation aspects, expression, and potential therapeutic strategies that could be based on tetraspanins and their interacting partners.

Indexed as

B cellimmune regulationpartnertetraspanintherapy strategy

Identifiers

PMID30072987
PMCPMC6058033
OpenAlexW2883376413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.