Evidence map›Paper›PMID 30072916›Full record

ArticleFrontiers in physiology2018

Atrial GIRK Channels Mediate the Effects of Vagus Nerve Stimulation on Heart Rate Dynamics and Arrhythmogenesis.

Steven W Lee, Allison Anderson, Pilar A Guzman, Atsushi Nakano, Elena G Tolkacheva, Kevin Wickman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
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  8. Relevance ofInternational journal of molecular sciences · 2023
    Review
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  11. Mechanism of PKCε regulation of cardiac GIRK channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Review
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  14. Protective effect of low-intensity treadmill exercise against acetylcholine-calcium chloride-induced atrial fibrillation in mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022
    Article
  15. Article
  16. Review
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  18. GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Vagus Nerve Stimulation and the Cardiovascular System.Cold Spring Harbor perspectives in medicine · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Steven W LeeDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States.
Allison AndersonDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, United States.
Pilar A GuzmanDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States.
Atsushi NakanoDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Elena G TolkachevaDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States.
Kevin WickmanDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, United States.
University of Minnesota · USUniversity of California, Los Angeles · US

Funding

The role of RGS proteins in the parasympathetic control of heart rateR01HL105550 · NHLBI · UNIVERSITY OF MINNESOTA · PI MARTEMYANOV, KIRILL A., WICKMAN, KEVIN D · 2011 to 2018
$3.2M
Metabolic regulation of heart formationR01HL142801 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NAKANO, ATSUSHI · 2019 to 2022
$1.6M
Hemogenic endocardium: contribution to the valvular tissue macrophagesR01HL127427 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NAKANO, ATSUSHI · 2016 to 2019
$1.5M
The role of electromechanical cue on cardiomyocyte maturationR21HL124503 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GIMZEWSKI, JAMES K, NAKANO, ATSUSHI · 2015 to 2016
$407k
Novel entropy based identification of rotors in human atrial fibrillationR21HL128790 · NHLBI · UNIVERSITY OF MINNESOTA · PI MULPURU, SIVA K, TALKACHOVA, ALENA · 2016 to 2017
$232k
Targeting the parasympathetic regulation of the heart to treat arrhythmiasF31HL139090 · NHLBI · UNIVERSITY OF MINNESOTA · PI ANDERSON, ALLISON DIANE · 2017 to 2019
$120k
Mending a Broken Heart with Vagal Nerve Stimulation and Stem Cell TherapyF31HL129544 · NHLBI · UNIVERSITY OF MINNESOTA · PI LEE, STEVEN W · 2015 to 2017
$71k
NHLBI NIH HHS F31 HL129544NHLBI NIH HHS F31 HL139090NHLBI NIH HHS R01 HL105550NHLBI NIH HHS R01 HL127427NHLBI NIH HHS R01 HL142801NHLBI NIH HHS R21 HL124503NHLBI NIH HHS R21 HL128790
6 · The paper itself

Abstract

Diminished parasympathetic influence is central to the pathogenesis of cardiovascular diseases, including heart failure and hypertension. Stimulation of the vagus nerve has shown promise in treating cardiovascular disease, prompting renewed interest in understanding the signaling pathway(s) that mediate the vagal influence on cardiac physiology. Here, we evaluated the contribution of G protein-gated inwardly rectifying K

Indexed as

arrhythmogenesisatrialGIRK channelKir3parasympatheticvagus nerve stimulation

Identifiers

PMID30072916
PMCPMC6060443
OpenAlexW2811424783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.