Evidence map›Paper›PMID 30072870›Full record

ArticleFrontiers in molecular neuroscience2018

Cryptochrome Interacts With Actin and Enhances Eye-Mediated Light Sensitivity of the Circadian Clock in

Matthias Schlichting, Dirk Rieger, Paola Cusumano, Rudi Grebler, Rodolfo Costa, Gabriella M Mazzotta, Charlotte Helfrich-Förster

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Sleep regulation inFrontiers in neuroscience · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. A PDZ scaffolding/CaM-mediated pathway in Cryptochrome signaling.Protein science : a publication of the Protein Society · 2024
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Light input pathways to the circadian clock of insects with an emphasis on the fruit fly Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020
    Review
  13. Journal of biological rhythms · 2020
    Review
  14. Model and Non-model Insects in Chronobiology.Frontiers in behavioral neuroscience · 2020
    Review
  15. Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Matthias SchlichtingNeurobiology and Genetics, Biocenter, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany.
Dirk RiegerNeurobiology and Genetics, Biocenter, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany.
Paola CusumanoDepartment of Biology, University of Padova, Padova, Italy.
Rudi GreblerNeurobiology and Genetics, Biocenter, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany.
Rodolfo CostaDepartment of Biology, University of Padova, Padova, Italy.
Gabriella M MazzottaDepartment of Biology, University of Padova, Padova, Italy.
Charlotte Helfrich-FörsterNeurobiology and Genetics, Biocenter, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany.
University of Padua · ITUniversity of Würzburg · DEBrandeis University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537
6 · The paper itself

Abstract

Cryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of circadian rhythmicity. Moreover, CRYs are sensing magnetic fields in insects as well as in humans. Here, we show that in the fruit fly

Indexed as

activity rhythmscryptochromeDrosophila melanogasterF-actinphototransduction

Identifiers

PMID30072870
PMCPMC6058042
OpenAlexW2809215343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.