ReviewPediatric research2018
Application of Neonatologist Performed Echocardiography in the assessment and management of persistent pulmonary hypertension of the newborn.
Review in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- International treatment outcomes of neonates on extracorporeal membrane oxygenation (ECMO) with persistent pulmonary hypertension of the newborn (PPHN): a systematic review.Journal of cardiothoracic surgery · 2024Pooled it
- Assessment of hemodynamic dysfunction in septic newborns by functional echocardiography: a systematic review.Pediatric research · 2024Pooled it
- Hemodynamic effects of high frequency oscillatory ventilation versus conventional mechanical ventilation in term neonates with persistent pulmonary hypertension: a single-center randomized trial.Italian journal of pediatrics · 2026Trial
- Nebulized nitroglycerin as an adjuvant drug in management of persistent pulmonary hypertension of newborns: a randomized controlled trial.European journal of pediatrics · 2025Trial
- Trial
- Nebulized Magnesium Sulfate for Treatment of Persistent Pulmonary Hypertension of Newborn: A Pilot Randomized Controlled Trial.Indian journal of pediatrics · 2021Trial
- Severe Suprasystemic Refractory Pulmonary Hypertension in a Neonate with Stüve-Wiedemann Syndrome Associated with Biallelic LIFR Variants: Molecular Insights and a Neonatal Case Report.International journal of molecular sciences · 2026Article
- Automated detection of neonatal pulmonary hypertension in echocardiograms with a deep learning model.Pediatric research · 2026Article
- Tissue Doppler Imaging, Pulmonary Haemodynamics and Conventional Echocardiographic Indices for Early Bronchopulmonary Dysplasia Prediction in Preterm Infants: A Prospective Observational Feasibility Study.Children (Basel, Switzerland) · 2026Article
- Reliability of two-dimensional versus M-mode echocardiography for left atrium/aortic diameter ratio and fractional shortening in extremely preterm infants.Pediatric research · 2026Article
- Physiology-Based Diagnosis and Management of Bronchopulmonary Dysplasia Associated Pulmonary Hypertension (BPD-PH).Children (Basel, Switzerland) · 2026Review
- [Selective interpretation of the "Guidelines and recommendations for targeted neonatal echocardiography and cardiac point-of-care ultrasound in the neonatal intensive care unit: an update from the American Society of Echocardiography"].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Assessing the Utility of Targeted Neonatal Echocardiography for Congenital Heart Disease Detection: Retrospective Cohort Analysis.Journal of clinical ultrasound : JCU · 2026Article
- Impact of the neonatal intensive critical ultrasound workflow for managing neonatal acute pulmonary hypertension.Frontiers in pediatrics · 2026Article
- Neonatologist-Performed Echocardiography in Neonatal Pulmonary Hypertension: A Narrative Review of the Literature.Diagnostics (Basel, Switzerland) · 2025Review
- Neonatal pulmonary hypertension in the NICU: a 10-year single-center experience.BMC pediatrics · 2025Article
- Characteristics and outcomes of preterm infants with early pulmonary hypertension.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- Persistent Pulmonary Hypertension of the Newborn: A Pragmatic Review of Pathophysiology, Diagnosis, and Advances in Management.Biomedicines · 2025Review
- Comment on "exploring minimally invasive tissue sampling as an alternative to conventional autopsy in neonatal deaths".Forensic science, medicine, and pathology · 2025Article
- Early postnatal right-to-left patent ductus arteriosus shunting and severe outcomes in neonates with congenital diaphragmatic hernia: a retrospective cohort study.BMC pediatrics · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary hypertension contributes to morbidity and mortality in both the term newborn infant, referred to as persistent pulmonary hypertension of the newborn (PPHN), and the premature infant, in the setting of abnormal pulmonary vasculature development and arrested growth. In the term infant, PPHN is characterized by the failure of the physiological postnatal decrease in pulmonary vascular resistance that results in impaired oxygenation, right ventricular failure, and pulmonary-to-systemic shunting. The pulmonary vasculature is either maladapted, maldeveloped, or underdeveloped. In the premature infant, the mechanisms are similar in that the early onset pulmonary hypertension (PH) is due to pulmonary vascular immaturity and its underdevelopment, while late onset PH is due to the maladaptation of the pulmonary circulation that is seen with severe bronchopulmonary dysplasia. This may lead to cor-pulmonale if left undiagnosed and untreated. Neonatologist performed echocardiography (NPE) should be considered in any preterm or term neonate that presents with risk factors suggesting PPHN. In this review, we discuss the risk factors for PPHN in term and preterm infants, the etiologies, and the pathophysiological mechanisms as they relate to growth and development of the pulmonary vasculature. We explore the applications of NPE techniques that aid in the correct diagnostic and pathophysiological assessment of the most common neonatal etiologies of PPHN and provide guidelines for using these techniques to optimize the management of the neonate with PPHN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.